Evidence map›Paper›PMID 29650710›Full record

ArticleJournal of the American Heart Association2018

Plasma Concentrations and Dietary Intakes of Choline and Betaine in Association With Atrial Fibrillation Risk: Results From 3 Prospective Cohorts With Different Health Profiles.

Hui Zuo, Gard F T Svingen, Grethe S Tell, Per M Ueland, Stein E Vollset, Eva R Pedersen, Arve Ulvik, Klaus Meyer, Jan E Nordrehaug, Dennis W T Nilsen and 2 more

Registry-linked trialOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00671346 (Combined Analyses and Long-term Follow-up in the Two Norwegian Homocysteine-Lowering B-Vitamin Trials NORVIT and WENBIT), which is not on this map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00671346 unknown statusnot on this map

Combined Analyses and Long-term Follow-up in the Two Norwegian Homocysteine-Lowering B-Vitamin Trials NORVIT and WENBIT

TypeobservationalSponsorHaukeland University HospitalRan1998 to 2021Enrolled6,839ConditionsCancer, Myocardial Infarction, Cerebrovascular Stroke
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Hui ZuoDepartment of Global Public Health and Primary Care, University of Bergen, Norway hui.zuo@uib.no.
Gard F T SvingenDepartment of Heart Disease, Haukeland University Hospital, Bergen, Norway.
Grethe S TellDepartment of Global Public Health and Primary Care, University of Bergen, Norway.
Per M UelandDepartment of Clinical Science, University of Bergen, Norway.
Stein E VollsetDepartment of Global Public Health and Primary Care, University of Bergen, Norway.
Eva R PedersenDepartment of Heart Disease, Haukeland University Hospital, Bergen, Norway.
Arve UlvikBevital A/S, Bergen, Norway.
Klaus MeyerBevital A/S, Bergen, Norway.
Jan E NordrehaugDepartment of Clinical Science, University of Bergen, Norway.
Dennis W T NilsenDepartment of Clinical Science, University of Bergen, Norway.
Kaare H BønaaDepartment of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Ottar NygårdDepartment of Clinical Science, University of Bergen, Norway.
University of Bergen · NOHaukeland University Hospital · NOBevital (Norway) · NOUiT The Arctic University of Norway · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough choline metabolism has been associated with atherosclerotic heart disease, less research attention has been paid to the associations of choline and its oxidative metabolite betaine with cardiac arrhythmias. METHODS AND

resultsWe evaluated associations of plasma concentrations and dietary intakes of choline and betaine with long-term atrial fibrillation (AF) risk in a community-based cohort, HUSK ([the Hordaland Health Study] n=6949), and validated the findings in 2 patient cohorts: the Western Norway Coronary Angiography Cohort (n=4164) and the NORVIT (Norwegian B-Vitamin) Trial (n=3733). Information on AF was obtained from the CVDNOR (Cardiovascular Disease in Norway) project. In HUSK, WECAC (Western Norway Coronary Angiography Cohort), and NORVIT, 552, 411, and 663 AF cases were identified during a median follow-up time of 10.9, 7.3, and, 8.7 years, respectively. Plasma concentrations of choline and betaine were significantly positively associated with later AF risk after multivariable adjustments in HUSK. Such associations were independently replicated in the 2 external prospective patient cohorts. The pooled hazard ratio was 1.13 (95% confidence interval 1.08-1.19,

conclusionsOur findings indicate that plasma concentrations as well as dietary intake of choline, but not betaine, are associated with subsequent risk of AF, suggesting a potential role of choline metabolism in the pathogenesis of AF. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov.Unique identifier: NCT00671346.

Indexed as

AgedAtrial FibrillationBetaineBiomarkersCholineDietFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedNorwayPrognosisProspective StudiesRisk AssessmentBetaineBiomarkersCholineatrial fibrillationbetainecholinecohort studiesthe CVDNOR project

Identifiers

PMID29650710
PMCPMC6015426
OpenAlexW2797658950

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.