Evidence map›Paper›PMID 29650693›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2018

High-Mobility Group Box 1 From Hypoxic Trophoblasts Promotes Endothelial Microparticle Production and Thrombophilia in Preeclampsia.

Yae Hu, Ruhong Yan, Ce Zhang, Zhichao Zhou, Meng Liu, Can Wang, Hong Zhang, Liang Dong, Tiantian Zhou, Yi Wu and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Extracellular vesicles in reproduction and pregnancy.Extracellular vesicles and circulating nucleic acids · 2022
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  13. Vascular Endothelial Cells and Innate Immunity.Arteriosclerosis, thrombosis, and vascular biology · 2020
    Review
  14. Article
  15. Annual Report on Sex in Preclinical Studies:Arteriosclerosis, thrombosis, and vascular biology · 2020
    Review
  16. Article
  17. Effects of Microvesicles on Cell Apoptosis under Hypoxia.Oxidative medicine and cellular longevity · 2019
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Yae HuFrom the Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Medical College, Soochow University, Suzhou, China (Y.H., R.Y., C.Z., Z.Z., M.L., C.W., L.D., T.Z., Y.W., N.D., Q.W.).
Ruhong YanFrom the Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Medical College, Soochow University, Suzhou, China (Y.H., R.Y., C.Z., Z.Z., M.L., C.W., L.D., T.Z., Y.W., N.D., Q.W.).
Ce ZhangFrom the Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Medical College, Soochow University, Suzhou, China (Y.H., R.Y., C.Z., Z.Z., M.L., C.W., L.D., T.Z., Y.W., N.D., Q.W.).
Zhichao ZhouFrom the Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Medical College, Soochow University, Suzhou, China (Y.H., R.Y., C.Z., Z.Z., M.L., C.W., L.D., T.Z., Y.W., N.D., Q.W.).
Meng LiuFrom the Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Medical College, Soochow University, Suzhou, China (Y.H., R.Y., C.Z., Z.Z., M.L., C.W., L.D., T.Z., Y.W., N.D., Q.W.).
Can WangFrom the Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Medical College, Soochow University, Suzhou, China (Y.H., R.Y., C.Z., Z.Z., M.L., C.W., L.D., T.Z., Y.W., N.D., Q.W.).
Hong ZhangDepartment of Obstetrics and Gynecology, the Second Affiliated Hospital of Soochow University, Suzhou, China (H.Z.).
Liang DongFrom the Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Medical College, Soochow University, Suzhou, China (Y.H., R.Y., C.Z., Z.Z., M.L., C.W., L.D., T.Z., Y.W., N.D., Q.W.).
Tiantian ZhouFrom the Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Medical College, Soochow University, Suzhou, China (Y.H., R.Y., C.Z., Z.Z., M.L., C.W., L.D., T.Z., Y.W., N.D., Q.W.).
Yi WuFrom the Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Medical College, Soochow University, Suzhou, China (Y.H., R.Y., C.Z., Z.Z., M.L., C.W., L.D., T.Z., Y.W., N.D., Q.W.).
Ningzheng DongFrom the Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Medical College, Soochow University, Suzhou, China (Y.H., R.Y., C.Z., Z.Z., M.L., C.W., L.D., T.Z., Y.W., N.D., Q.W.) wuq@ccf.org ningzhengdong@suda.edu.cn.
Qingyu WuFrom the Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Medical College, Soochow University, Suzhou, China (Y.H., R.Y., C.Z., Z.Z., M.L., C.W., L.D., T.Z., Y.W., N.D., Q.W.) wuq@ccf.org ningzhengdong@suda.edu.cn.
Zunyi Medical University · CNSoochow University · CNFirst Affiliated Hospital of Soochow University · CNNantong University · CNSecond Affiliated Hospital of Soochow University · CN

Funding

Serine Protease Corin in Pregnancy-induced HypertensionR01HD064634 · NICHD · CLEVELAND CLINIC LERNER COM-CWRU · PI WU, QINGYU · 2011 to 2015
$1.6M
Molecular Mechanisms In Corin ActivationR01HL126697 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI WU, QINGYU · 2015 to 2018
$1.6M
NHLBI NIH HHS R01 HL126697NICHD NIH HHS R01 HD064634
6 · The paper itself

Abstract

objectiveThrombophilia is a major complication in preeclampsia, a disease associated with placental hypoxia and trophoblast inflammation. Preeclampsia women are known to have increased circulating microparticles that are procoagulant, but the underlying mechanisms remain unclear. In this study, we sought to understand the mechanism connecting placental hypoxia, circulating microparticles, and thrombophilia. APPROACH AND

resultsWe analyzed protein markers on plasma microparticles from preeclampsia women and found that the increased circulating microparticles were mostly from endothelial cells. In proteomic studies, we identified HMGB1 (high-mobility group box 1), a proinflammatory protein, as a key factor from hypoxic trophoblasts in stimulating microparticle production in human umbilical vein endothelial cells. Immunodepletion or inhibition of HMGB1 in the conditioned medium from hypoxic human trophoblasts abolished the endothelial microparticle-stimulating activity. Conversely, recombinant HMGB1 stimulated microparticle production in cultured human umbilical vein endothelial cells. The microparticles from recombinant HMGB1-stimulated human umbilical vein endothelial cells promoted blood coagulation and neutrophil activation in vitro. Injection of recombinant HMGB1 in pregnant mice increased plasma endothelial microparticles and promoted blood coagulation. In preeclampsia women, elevated placental HMGB1 expression was detected and high levels of plasma HMGB1 correlated with increased plasma endothelial microparticles.

conclusionsOur results indicate that placental hypoxia-induced HMGB1 expression and release from trophoblasts are important mechanism underlying increased circulating endothelial microparticles and thrombophilia in preeclampsia.

Indexed as

Blood CoagulationParacrine CommunicationAnimalsCase-Control StudiesCell-Derived MicroparticlesCell HypoxiaCell LineFemaleHMGB1 ProteinHumansHuman Umbilical Vein Endothelial CellsMice, Inbred C57BLNeutrophil ActivationPre-EclampsiaPregnancySignal TransductionHMGB1 ProteinHMGB1 protein, humanblood coagulationendothelial cellsHMGB1 proteinpre-eclampsiathrombophilia

Identifiers

PMID29650693
PMCPMC5970057
OpenAlexW2796874012

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.