Evidence map›Paper›PMID 29650591›Full record

ArticleDevelopment (Cambridge, England)2018

Ldb1- and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in the retina.

Jimmy de Melo, Brian S Clark, Anand Venkataraman, Fion Shiau, Cristina Zibetti, Seth Blackshaw

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jimmy de MeloSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-9393-9217
Brian S ClarkSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Anand VenkataramanSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-6303-4820
Fion ShiauSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Cristina ZibettiSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-4922-1245
Seth BlackshawSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA sblack@jhmi.edu.ORCID 0000-0002-1338-8476
Johns Hopkins University · US

Funding

Transcriptional regulation of retinal cell differentiation and functionR01EY020560 · NEI · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH · 2011 to 2021
$4.4M
Identification of the molecular mechanisms mediating intrinsic control of retinal progenitor competenceK99EY027844 · NEI · JOHNS HOPKINS UNIVERSITY · PI CLARK, BRIAN S · 2017 to 2018
$205k
Regulation of Retinal Progenitor Cell Competence by Long noncoding RNAsF32EY024201 · NEI · JOHNS HOPKINS UNIVERSITY · PI CLARK, BRIAN S · 2014 to 2016
$164k
NEI NIH HHS F32 EY024201NEI NIH HHS K99 EY027844NEI NIH HHS R01 EY020560
6 · The paper itself

Abstract

Precise control of the relative ratio of retinal neurons and glia generated during development is essential for visual function. We show that

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsDNA-Binding ProteinsEpendymoglial CellsLIM Domain ProteinsLIM-Homeodomain ProteinsMiceMice, TransgenicNerve Tissue ProteinsNeurogenesisRetinal NeuronsTranscription FactorsUbiquitin-Protein LigasesAscl2 protein, mouseBasic Helix-Loop-Helix ProteinsDNA-Binding ProteinsLdb1 protein, mouseLhx2 protein, mouseLIM Domain ProteinsLIM-Homeodomain ProteinsNerve Tissue ProteinsNeurog2 protein, mouseRlim protein, mouseTranscription FactorsUbiquitin-Protein LigasesCell fateCo-factorGliogenesisNeurogenesisRetinaTranscription factor

Identifiers

PMID29650591
PMCPMC5992592
OpenAlexW2950705493

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.