Evidence map›Paper›PMID 29650545›Full record

ArticleCirculation2018

Regulation of Blood Pressure by Targeting Ca

Zhenyu Hu, Guang Li, Jiong-Wei Wang, Suet Yen Chong, Dejie Yu, Xiaoyuan Wang, Jia Lin Soon, Mui Cheng Liang, Yuk Peng Wong, Na Huang and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 36 citations in OpenAlex.

  1. Healing mechanisms of Galectin-1 in the ischemic heart.Cell biochemistry and biophysics · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Probing the CabioRxiv : the preprint server for biology · 2025
    Article
  8. Rad-mediated inhibition of CaThe Journal of physiology · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Modulation of CaHandbook of experimental pharmacology · 2023
    Article
  13. Oxidative Regulation of Vascular CaAntioxidants (Basel, Switzerland) · 2022
    Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Zhenyu HuDepartment of Physiology, Yong Loo Lin School of Medicine (Z.Y.H., J.-W.W., D.Y., M.C.L., Y.P.W., T.W.S.), National University of Singapore.
Guang LiKey Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China (G.L.).
Jiong-Wei WangDepartment of Physiology, Yong Loo Lin School of Medicine (Z.Y.H., J.-W.W., D.Y., M.C.L., Y.P.W., T.W.S.), National University of Singapore.
Suet Yen ChongDepartment of Surgery, Yong Loo Lin School of Medicine (J.-W.W., S.Y.C., X.W.), National University of Singapore.
Dejie YuDepartment of Physiology, Yong Loo Lin School of Medicine (Z.Y.H., J.-W.W., D.Y., M.C.L., Y.P.W., T.W.S.), National University of Singapore.
Xiaoyuan WangDepartment of Surgery, Yong Loo Lin School of Medicine (J.-W.W., S.Y.C., X.W.), National University of Singapore.
Jia Lin SoonNational Heart Centre Singapore (J.L.S., N.H.).
Mui Cheng LiangDepartment of Physiology, Yong Loo Lin School of Medicine (Z.Y.H., J.-W.W., D.Y., M.C.L., Y.P.W., T.W.S.), National University of Singapore.
Yuk Peng WongDepartment of Physiology, Yong Loo Lin School of Medicine (Z.Y.H., J.-W.W., D.Y., M.C.L., Y.P.W., T.W.S.), National University of Singapore.
Na HuangNational Heart Centre Singapore (J.L.S., N.H.).
Henry M ColecraftDepartment of Physiology and Cellular Biophysics, Columbia University, College of Physicians and Surgeons, New York (H.M.C.).
Ping LiaoCalcium Signaling Laboratory (P.L.).
Tuck Wah SoongDepartment of Physiology, Yong Loo Lin School of Medicine (Z.Y.H., J.-W.W., D.Y., M.C.L., Y.P.W., T.W.S.), National University of Singapore.
National University of Singapore · SGColumbia University · USNational Heart Centre Singapore · SGNational University Heart Centre Singapore · SGSouthwest Medical University · CN

Funding

L-type channel trafficking and modulation in heartR01HL121253 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Henry M. Colecraft, Steven O Marx · 2014 to 2026
$8.4M
NHLBI NIH HHS R01 HL121253
6 · The paper itself

Abstract

backgroundL-type Ca

methodsIn vitro experiments involving coimmunoprecipitation, Western blot, patch-clamp recordings, immunohistochemistry, and pressure myography were used to evaluate the molecular mechanisms by which Gal-1 downregulates Ca

resultsOur study reveals that Gal-1 is a key regulator for proteasomal degradation of Ca

conclusionsWe have defined molecularly that Gal-1 promotes Ca

Indexed as

AnimalsAntihypertensive AgentsArterial PressureCalcium Channels, L-TypeCase-Control StudiesDependovirusDisease Models, AnimalGalectin 1Genetic TherapyGenetic VectorsHEK293 CellsHumansHypertensionMaleMembrane PotentialsMice, KnockoutAntihypertensive AgentsCACNA1C protein, humanCACNA1C protein, mouseCacna1c protein, ratCalcium Channels, L-TypeGalectin 1LGALS1 protein, humanLgals1 protein, mouseLgals1 protein, ratPeptide FragmentsProteasome Endopeptidase Complexblood pressurecalcium channels, L typegalectin-1hypertensionproteasome endopeptidase complex

Identifiers

PMID29650545
PMCPMC6185826
OpenAlexW2796765838

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.