ArticleBMC medicine2018
Prediction of autonomic dysreflexia during urodynamics: a prospective cohort study.
Article in BMC medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01293110 (Database of Patients With Lower Urinary Tract Dysfunction Treated at the University of Zürich), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Database of Patients With Lower Urinary Tract Dysfunction Treated at the University of Zürich
Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Intradetrusor OnabotulinumtoxinA Injections Ameliorate Autonomic Dysreflexia while Improving Lower Urinary Tract Function and Urinary Incontinence-Related Quality of Life in Individuals with Cervical and Upper Thoracic Spinal Cord Injury.Journal of neurotrauma · 2020Trial
- Ice Water Test Unmasks Detrusor Overactivity in Apparently Normal Conventional Cystometry.European urology open science · 2026Article
- A Pilot Feasibility Trial of Multi-Program Epidural Spinal Cord Stimulation for Bladder Function Recovery in Chronic Spinal Cord Injury.Journal of clinical medicine · 2026Article
- Neurogenic Pelvic Floor Dysfunctions Across Neurological Disorders: Mechanisms, Phenotypes, and Precision Rehabilitation Pathways-A Narrative Review.Journal of clinical medicine · 2026Review
- Managing autonomic dysreflexia during urological care in individuals living with spinal cord injury.Nature reviews. Urology · 2025Article
- Urodynamic evaluation of neurogenic bladder in patients with spinal cord injury within 6 months post-injury: a Retrospective Cross-Sectional Study.Spinal cord · 2025Article
- Autonomic dysreflexia in urological practice: pathophysiology, prevention and treatment considerations.World journal of urology · 2024Review
- Prediction of Lower Urinary Tract, Sexual, and Bowel Function, and Autonomic Dysreflexia after Spinal Cord Injury.Biomedicines · 2023Review
- Neurogenic Lower Urinary Tract Dysfunction in the First Year After Spinal Cord Injury: A Descriptive Study of Urodynamic Findings.The Journal of urology · 2023Article
- Automatic detection of the mental state in responses towards relaxation.Neural computing & applications · 2023Article
- Targeting bladder function with network-specific epidural stimulation after chronic spinal cord injury.Scientific reports · 2022Article
- Remodeling of extracellular matrix in the urinary bladder of paraplegic rats results in increased compliance and delayed fiber recruitment 16 weeks after spinal cord injury.Acta biomaterialia · 2022Article
- Diastolic blood pressure changes during episodes of autonomic dysreflexia.The journal of spinal cord medicine · 2021Article
- Long-term neurogenic lower urinary tract dysfunction: A case of cardiovascular nightmares.The journal of spinal cord medicine · 2021Article
- Quantitative analysis of dysautonomia in patients with autonomic dysreflexia.Journal of neurology · 2021Article
- Reduced Reflex Autonomic Responses Following Intradetrusor OnabotulinumtoxinA Injections: A Pre-/Post-study in Individuals With Cervical and Upper Thoracic Spinal Cord Injury.Frontiers in physiology · 2021Article
- Automated Detection of Symptomatic Autonomic Dysreflexia Through Multimodal Sensing.IEEE journal of translational engineering in health and medicine · 2020Article
- Article
- Early urological care of patients with spinal cord injury.World journal of urology · 2018Review
- Epidural Spinal Cord Stimulation Acutely Modulates Lower Urinary Tract and Bowel Function Following Spinal Cord Injury: A Case Report.Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutonomic dysreflexia is a severe and potentially life-threatening condition in patients with spinal cord injury, as it can lead to myocardial ischemia, brain hemorrhage, or even death. Urodynamic investigation is the gold standard to assess neurogenic lower urinary tract dysfunction due to spinal cord injury and reveal crucial pathological findings, such as neurogenic detrusor overactivity. However, neurogenic detrusor overactivity and urodynamic investigation are known to be leading triggers of autonomic dysreflexia. Therefore, we aimed to determine predictors of autonomic dysreflexia in individuals with spinal cord injury during urodynamic investigation.
methodsThis prospective cohort study included 300 patients with spinal cord injuries and complete datasets of continuous non-invasive cardiovascular monitoring, recorded during same session repeat urodynamic investigation. We used logistic regression to reveal predictors of autonomic dysreflexia during urodynamic investigation.
resultsWe found that level of injury and presence of neurogenic detrusor overactivity were the only two independent significant predictors for autonomic dysreflexia during urodynamic investigation. A lesion at spinal segment T6 or above (odds ratio (OR) 5.5, 95% CI 3.2-9.4) compared to one at T7 or below, and presence of neurogenic detrusor overactivity (OR 2.7, 95% confidence interval (CI) 1.4-4.9) were associated with a significant increased odds of autonomic dysreflexia during urodynamic investigation. Both odds persisted after adjustment for age, sex, and completeness and stage of injury (adjusted OR (AOR) 6.6, 95% CI 3.8-11.7, and AOR 2.2, 95% CI 1.1-4.5, respectively). Further stratification by lesion level showed level-dependent significantly increased adjusted odds of autonomic dysreflexia, i.e., from C1-C4 (AOR 16.2, 95% CI 5.9-57.9) to T4-T6 (AOR 2.6, 95% CI 1.3-5.2), compared to lesions at T7 or below.
conclusionsIn patients with neurogenic lower urinary tract dysfunction due to spinal cord injury, autonomic dysreflexia is independently predicted by lesion level and presence of neurogenic detrusor overactivity. Considering the health risks associated with autonomic dysreflexia, such as seizures, stroke, retinal bleeding, or even death, we recommend both continuous cardiovascular monitoring during urodynamic investigation in all spinal cord-injured patients with emphasis on those with cervical lesions, and appropriate neurogenic detrusor overactivity treatment to reduce the probability of potentially life-threatening complications.
trial registrationClinicalTrials.gov, NCT01293110 .
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.