ArticleIntegrative cancer therapies2018
Effects of an Exercise Intervention on Cancer-Related Fatigue and Its Relationship to Markers of Oxidative Stress.
Article in Integrative cancer therapies, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- The effect of physical activity on markers of oxidative and antioxidant stress in cancer patients: a systematic review and meta-analysis.BMC cancer · 2025Pooled it
- Behaviour change techniques used in lifestyle interventions that aim to reduce cancer-related fatigue in cancer survivors: a systematic review.The international journal of behavioral nutrition and physical activity · 2023Pooled it
- Exercise and Oxidative Stress Biomarkers among Adult with Cancer: A Systematic Review.Oxidative medicine and cellular longevity · 2022Pooled it
- Pooled it
- Efficacy and safety of bupropion in cancer-related fatigue, a randomized double blind placebo controlled clinical trial.BMC cancer · 2020Trial
- Resistance Exercise: A Potential Intervention for Managing Cardiovascular Health in Individuals with a History of Cancer.Sports medicine - open · 2026Article
- Cancer Cachexia.Advances in experimental medicine and biology · 2025Review
- Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia.Cancers · 2024Review
- Article
- Metabolic underpinnings of cancer-related fatigue.American journal of physiology. Endocrinology and metabolism · 2024Review
- Feasibility and Safety of Food ContainingPalliative medicine reports · 2024Article
- Inflammatory, Oxidative Stress, and Cardiac Damage Biomarkers and Radiation-Induced Fatigue in Breast Cancer Survivors.Biological research for nursing · 2022Article
- Voluntary wheel running ameliorates select paclitaxel chemotherapy-induced sickness behaviors and associated melanocortin signaling.Behavioural brain research · 2021Article
- Structured Exercise in Cancer Survivors: Is it Enough for Neural, Mental Health and Well-being?International journal of exercise science · 2021Article
- Exercise as a therapy for cancer-induced muscle wasting.Sports medicine and health science · 2020Review
- Review
- Oncology and Cardiac Rehabilitation: An Underrated Relationship.Journal of clinical medicine · 2020Review
- Effect of Traditional Chinese Medicine Injection on Cancer-Related Fatigue: A Meta-Analysis Based on Existing Evidence.Evidence-based complementary and alternative medicine : eCAM · 2020Review
- Exercise stimulates beneficial adaptations to diminish doxorubicin-induced cellular toxicity.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Review
- Exercise as Adjunct Therapy in Cancer.Seminars in radiation oncology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the underlying mechanisms of cancer-related fatigue (CRF) are not fully characterized, treatment-associated oxidative stress may play a role. The purpose of this study was to determine the effect of an exercise intervention on the relationship between CRF and oxidative stress.
methodsUpon cessation of radiation or chemotherapy, 8 cancer patients participated in a 10-week exercise intervention (EX), while 7 continued standard care (CON). Blood draws and fatigue questionnaires were administered to cancer patients before and after the intervention as well as to 7 age-matched individuals with no cancer history. Changes in plasma 8-hydroxy-deoxyguanosine (8-OHdG), protein carbonyls, antioxidant capacity, and fatigue were compared between groups. Correlations between CRF and oxidative stress were evaluated.
resultsMean total fatigue scores decreased significantly (5.0 ± 2.2 to 2.6 ± 1.5, P < .05) in EX, but not in CON. Antioxidant capacity significantly increased (+41%; P < .05) and protein carbonyls significantly decreased (-36%; P < .05) in EX, but not in CON. Increases in antioxidant capacity were significantly correlated with reductions in affective ( r = -.49), sensory ( r = -.47), and cognitive fatigue ( r = -.58). Changes in total ( r = .46) and affective ( r = .47) fatigue exhibited significant correlations with changes in 8-OHdG over time, while behavioral ( r = .46) and sensory ( r = .47) fatigue changes were significantly correlated with protein carbonyls.
conclusionsOxidative stress may be implicated in CRF, while improved antioxidant capacity following an exercise intervention may play a role in mitigating CRF in cancer survivors.
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Registered trials
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