ArticleNeonatology2018
Relation of Retinopathy of Prematurity to Brain Volumes at Term Equivalent Age and Developmental Outcome at 2 Years of Corrected Age in Very Preterm Infants.
Article in Neonatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Postnatal serum IGF-1 levels associate with brain volumes at term in extremely preterm infants.Pediatric research · 2023Trial
- Effect of enteral arachidonic acid and docosahexaenoic acid supplementation on brain volumes at term in preterm infants: a secondary outcome analysis of a randomised controlled trial.Archives of disease in childhood. Fetal and neonatal edition · 2026Article
- Tracking visual outcomes - Follow-up on patients born preterm with childhood-onset visual impairment.Acta ophthalmologica · 2025Article
- Early medical risks to language development in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- A comparative study of stereopsis in term and preterm children with and without retinopathy of prematurity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Congenital Malformations of the Eye: A Pictorial Review and Clinico-Radiological Correlations.Journal of ophthalmology · 2024Review
- ROP: 80 Years after Its Detection - Where Do We Stand and How Long Will We Continue to Laser?Neonatology · 2024Review
- Relationships between retinopathy of prematurity without ophthalmologic intervention and neurodevelopment and vision at 2 years.Pediatric research · 2023Article
- Association between severe retinopathy of prematurity (ROP) and poor motor neurodevelopmental outcome.Indian journal of ophthalmology · 2023Review
- Risk Factors of Language Delay at Two Years of Corrected Age among Very-Low-Birth-Weight Preterm Infants: A Population-Based Study.Children (Basel, Switzerland) · 2023Article
- Retinopathy of prematurity and neurodevelopmental outcomes in preterm infants: A systematic review and meta-analysis.Frontiers in pediatrics · 2023Review
- Early factors associated with risk of developmental coordination disorder in very preterm children: A prospective area-based cohort study in Italy.Paediatric and perinatal epidemiology · 2022Article
- Article
- Neurosensory Alterations in Retinopathy of Prematurity: A Window to Neurological Impairments Associated to Preterm Birth.Biomedicines · 2022Review
- Visuopathy of prematurity: is retinopathy just the tip of the iceberg?Pediatric research · 2022Review
- Maternal and Neonatal Polyunsaturated Fatty Acid Intake and Risk of Neurodevelopmental Impairment in Premature Infants.International journal of molecular sciences · 2022Review
- Association of Severe Retinopathy of Prematurity and Bronchopulmonary Dysplasia with Adverse Neurodevelopmental Outcomes in Preterm Infants without Severe Brain Injury.Brain sciences · 2021Article
- Analysis of Brain Injury Biomarker Neurofilament Light and Neurodevelopmental Outcomes and Retinopathy of Prematurity Among Preterm Infants.JAMA network open · 2021Article
- Brain White Matter Maturation and Early Developmental Outcomes in Preterm Infants With Retinopathy of Prematurity.Investigative ophthalmology & visual science · 2021Observational
- High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born <24 gestational weeks.BMJ open ophthalmology · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundRetinopathy of prematurity (ROP) is a major complication of preterm birth and has been associated with later visual and nonvisual impairments.
objectivesTo evaluate relationships between any stage of ROP, brain volumes, and developmental outcomes.
methodsThis study included 52 very preterm infants (gestational age [mean ± SD]: 26.4 ± 1.9 weeks). Total brain, gray matter, unmyelinated white matter (UWMV), and cerebellar volumes were estimated in 51 out of 52 infants by magnetic resonance imaging at term-equivalent age. Bayley Scales of Infant Development were used to assess developmental outcomes in 49 out of 52 infants at a mean corrected age of 24.6 months.
resultsNineteen out of 52 infants developed any stage of ROP. Infants with ROP had a lower median (IQR) UWMV (173 [156-181] vs. 204 [186-216] mL, p < 0.001) and cerebellar volume (18.3 [16.5-20] vs. 22.3 [20.3-24.7] mL, p < 0.001) than infants without ROP. They also had a lower median (IQR) mental developmental index (72 [56-83] vs. 100 [88-104], p < 0.001) and a lower psychomotor developmental index (80 [60-85] vs. 92 [81-103], p = 0.002). Brain volumes and developmental outcomes did not differ among infants with different stages of ROP.
conclusionAny stage of ROP in preterm infants was associated with a reduced brain volume and an impaired developmental outcome. These results suggest that common pathways may lead to impaired neural and neurovascular development in the brain and retina and that all stages of ROP may be considered in future studies on ROP and development.
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