ReviewCurrent opinion in neurobiology2018
Probing the brain with molecular fMRI.
Review in Current opinion in neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.Trends in neurosciences · 2025Review
- Direct observation of NMR transverse relaxation in nanopatterned clusters of iron oxide particles.Magnetic resonance in medicine · 2024Article
- Mapping light distribution in tissue by using MRI-detectable photosensitive liposomes.Nature biomedical engineering · 2023Article
- Simultaneous Functional Magnetic Resonance and Optoacoustic Imaging of Brain-Wide Sensory Responses in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Probing nitric oxide signaling using molecular MRI.Free radical biology & medicine · 2022Review
- Reporter Genes for Brain Imaging Using MRI, SPECT and PET.International journal of molecular sciences · 2022Review
- Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators.Nature reviews. Neuroscience · 2022Review
- Molecular fMRI of neurochemical signaling.Journal of neuroscience methods · 2021Review
- Emerging imaging methods to study whole-brain function in rodent models.Translational psychiatry · 2021Review
- Calcium-responsive contrast agents for functional magnetic resonance imaging.Chemical physics reviews · 2021Review
- Review
- Linking the nature and functions of sleep: insights from multimodal imaging of the sleeping brain.Current opinion in physiology · 2020Review
- Target-responsive vasoactive probes for ultrasensitive molecular imaging.Nature communications · 2020Article
- Neurotransmitter-Responsive Nanosensors forJournal of the American Chemical Society · 2019Article
- Early detection and monitoring of cerebral ischemia using calcium-responsive MRI probes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- MRI-guided robotic arm drives optogenetic fMRI with concurrent CaNature communications · 2019Article
- Sensing intracellular calcium ions using a manganese-based MRI contrast agent.Nature communications · 2019Article
- Multi-Modal Nano Particle Labeling of Neurons.Frontiers in neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
One of the greatest challenges of modern neuroscience is to incorporate our growing knowledge of molecular and cellular-scale physiology into integrated, organismic-scale models of brain function in behavior and cognition. Molecular-level functional magnetic resonance imaging (molecular fMRI) is a new technology that can help bridge these scales by mapping defined microscopic phenomena over large, optically inaccessible regions of the living brain. In this review, we explain how MRI-detectable imaging probes can be used to sensitize noninvasive imaging to mechanistically significant components of neural processing. We discuss how a combination of innovative probe design, advanced imaging methods, and strategies for brain delivery can make molecular fMRI an increasingly successful approach for spatiotemporally resolved studies of diverse neural phenomena, perhaps eventually in people.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.