Evidence map›Paper›PMID 29649711›Full record

ArticleJournal of affective disorders2018

The interaction of BDNF Val66Met, PTSD, and child abuse on psychophysiological reactivity and HPA axis function in a sample of Gulf War Veterans.

Dmitri A Young, Thomas C Neylan, Aoife O'Donovan, Thomas Metzler, Anne Richards, Jessica A Ross, Sabra S Inslicht

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Dmitri A YoungSan Francisco VA Healthcare System, 4150 Clement St. (116P), San Francisco, CA 94121, USA; Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA; Northern California Institute for Research and Education (NCIRE), The Veterans Health Research Institute, San Francisco, CA 94121, USA. Electronic address: dmitri.young@ucsf.edu.
Thomas C NeylanSan Francisco VA Healthcare System, 4150 Clement St. (116P), San Francisco, CA 94121, USA; Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA; Northern California Institute for Research and Education (NCIRE), The Veterans Health Research Institute, San Francisco, CA 94121, USA.
Aoife O'DonovanSan Francisco VA Healthcare System, 4150 Clement St. (116P), San Francisco, CA 94121, USA; Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA; Northern California Institute for Research and Education (NCIRE), The Veterans Health Research Institute, San Francisco, CA 94121, USA.
Thomas MetzlerSan Francisco VA Healthcare System, 4150 Clement St. (116P), San Francisco, CA 94121, USA; Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA; Northern California Institute for Research and Education (NCIRE), The Veterans Health Research Institute, San Francisco, CA 94121, USA.
Anne RichardsSan Francisco VA Healthcare System, 4150 Clement St. (116P), San Francisco, CA 94121, USA; Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA; Northern California Institute for Research and Education (NCIRE), The Veterans Health Research Institute, San Francisco, CA 94121, USA.
Jessica A RossDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA.
Sabra S InslichtSan Francisco VA Healthcare System, 4150 Clement St. (116P), San Francisco, CA 94121, USA; Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA; Northern California Institute for Research and Education (NCIRE), The Veterans Health Research Institute, San Francisco, CA 94121, USA.
University of California, San Francisco · US

Funding

Effects of inflammation on neural mechanisms of threat sensitivity in posttraumatic stress disorderK01MH109871 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI O'DONOVAN, AOIFE · 2016 to 2019
$737k
NIMH NIH HHS K01 MH109871
6 · The paper itself

Abstract

introductionWhile the BDNF Val66Met polymorphism has been linked to various psychological disorders, limited focus has been on its relationship to posttraumatic stress disorder (PTSD) and early traumas such as child abuse. Therefore, we assessed whether Val66Met was associated with fear potentiated psychophysiological response and HPA axis dysfunction and whether PTSD status or child abuse history moderated these outcomes in a sample of Veterans.

methods226 and 173 participants engaged in a fear potentiated acoustic startle paradigm and a dexamethasone suppression test (DST) respectively. Fear conditions included no, ambiguous, and high threat conditions. Psychophysiological response measures included electromyogram (EMG), skin conductance response (SCR), and heart rate. The Clinician Administered PTSD Scale (CAPS) and the Trauma History Questionnaire (THQ) were used to assess PTSD status and child abuse history respectively.

resultsMet allele carriers exhibited greater SCR magnitudes in the no and ambiguous threat conditions (p < 0.01 and p < 0.05 respectively). Met carriers with PTSD exhibited greater physiological response magnitudes in the ambiguous (SCR, p < 0.001) and high threat conditions (SCR and heart rate, both p ≤ 0.005). Met carrier survivors of child abuse exhibited blunted heart rate magnitudes in the high threat condition (p < 0.01). Met allele carries with PTSD also exhibited greater percent cortisol suppression (p < 0.005). LIMITATIONS: Limitations included small sample size and the cross-sectional nature of the data.

conclusionsThe Val66met may impact PTSD susceptibility differentially via enhanced threat sensitivity and HPA axis dysregulation. Child abuse may moderate Val66Met's impact on threat reactivity. Future research should explore how neuronal mechanisms might mediate this risk.

Indexed as

Adaptation, PsychologicalAdultAdult Survivors of Child AbuseAllelesBrain-Derived Neurotrophic FactorCross-Sectional StudiesFearFemaleGenetic Predisposition to DiseaseGulf WarHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleMiddle AgedPituitary-Adrenal SystemBDNF protein, humanBrain-Derived Neurotrophic FactorHydrocortisoneChild abuseDexamethasone suppression testPsychophysiological responsePTSDVal66Met

Identifiers

PMID29649711
PMCPMC6354935
OpenAlexW2796235140

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.