ArticleDevelopmental and comparative immunology2018
The interplay between dose and immune system activation determines fungal infection outcome in the African malaria mosquito, Anopheles gambiae.
Article in Developmental and comparative immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 51 citations in OpenAlex.
- Distinct roles of theCurrent research in insect science · 2026Article
- The transcriptional response in mosquitoes distinguishes between fungi and bacteria but not Gram types.BMC genomics · 2024Article
- Mapping the functional form of the trade-off between infection resistance and reproductive fitness under dysregulated immune signaling.PLoS pathogens · 2024Article
- Toll and IMD Immune Pathways Are Important Antifungal Defense Components in a Pupal Parasitoid,International journal of molecular sciences · 2023Article
- Beauveria bassiana interacts with gut and hemocytes to manipulate Aedes aegypti immunity.Parasites & vectors · 2023Article
- A zone-of-inhibition assay to screen for humoral antimicrobial activity in mosquito hemolymph.Frontiers in cellular and infection microbiology · 2023Article
- Malaria-Transmitting Vectors Microbiota: Overview and Interactions WithFrontiers in microbiology · 2022Review
- C-type lectin 4 regulates broad-spectrum melanization-based refractoriness to malaria parasites.PLoS biology · 2022Article
- The mosquito melanization response requires hierarchical activation of non-catalytic clip domain serine protease homologs.PLoS pathogens · 2019Article
- Mosquito-fungus interactions and antifungal immunity.Insect biochemistry and molecular biology · 2019Review
- Transstadial immune activation in a mosquito: Adults that emerge from infected larvae have stronger antibacterial activity in their hemocoel yet increased susceptibility to malaria infection.Ecology and evolution · 2019Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The Toll pathway is a central regulator of antifungal immunity in insects. In mosquitoes, the Toll pathway affects infections with the fungal entomopathogen, Beauveria bassiana, which is considered a potential mosquito biopesticide. We report here the use of B. bassiana strain I93-825 in Anopheles gambiae to analyze the impact of Toll pathway modulation on mosquito survival. Exposure to a narrow dose range of conidia by direct contact decreased mosquito longevity and median survival. In addition, fungal exposure dose correlated positively and linearly with hazard ratio. Increased Toll signaling by knockdown of its inhibitor, cactus, decreased survivorship of uninfected females, increased mosquito survival after low dose B. bassiana exposure, but had little effect following exposure to higher doses. This observed trade-off could have implications for development of B. bassiana as a prospective vector control tool. On the one hand, selection for small increases in mosquito immune signaling across a narrow dose range could impair efficacy of B. bassiana. On the other hand, costs of immunity and the capacity for higher doses of fungus to overwhelm immune responses could limit evolution of resistance.
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