ArticleArchives of physical medicine and rehabilitation2018
Associations Between Muscle Synergies and Treatment Outcomes in Cerebral Palsy Are Robust Across Clinical Centers.
Article in Archives of physical medicine and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Muscle Synergies During Walking in Children With Cerebral Palsy: A Systematic Review.Frontiers in physiology · 2020Pooled it
- Walking Environment and Speed Differentially Change More Affected Limb Dynamic Motor Control in Children With Cerebral Palsy.Neurorehabilitation and neural repair · 2026Article
- Body-weight support is the primary driver of elevated walking cost in cerebral palsy.Research square · 2026Article
- Muscle synergies are largely unaffected in individuals with diabetes who do not have diabetic neuropathy.Clinical biomechanics (Bristol, Avon) · 2025Article
- Can muscle synergies shed light on the mechanisms underlying motor gains in response to robot-assisted gait training in children with cerebral palsy?Journal of neuroengineering and rehabilitation · 2025Article
- Characterization of muscle synergy similarity and adaptation in hip exoskeleton-assisted locomotion.Frontiers in bioengineering and biotechnology · 2025Article
- Factors influencing neuromuscular responses to gait training with a robotic ankle exoskeleton in cerebral palsy.Assistive technology : the official journal of RESNA · 2023Article
- Motor control complexity can be dynamically simplified during gait pattern exploration using motor control-based biofeedback.Journal of neurophysiology · 2023Article
- A longitudinal analysis of selective motor control during gait in individuals with cerebral palsy and the relation to gait deviations.PloS one · 2023Article
- Recent developments in muscle synergy analysis in young people with neurodevelopmental diseases: A Systematic Review.Frontiers in bioengineering and biotechnology · 2023Review
- Individuals with Chronic Mild-to-Moderate Traumatic Brain Injury Exhibit Decreased Neuromuscular Complexity During Gait.Neurorehabilitation and neural repair · 2022Article
- A muscle synergy-based method to estimate muscle activation patterns of children with cerebral palsy using data collected from typically developing children.Scientific reports · 2022Article
- Is modular control related to functional outcomes in individuals with knee osteoarthritis and following total knee arthroplasty?PloS one · 2022Article
- Causal Effects of Motor Control on Gait Kinematics After Orthopedic Surgery in Cerebral Palsy: A Machine-Learning Approach.Frontiers in human neuroscience · 2022Article
- Neuromuscular Control before and after Independent Walking Onset in Children with Cerebral Palsy.Sensors (Basel, Switzerland) · 2021Article
- Greater Reliance on Cerebral Palsy-Specific Muscle Synergies During Gait Relates to Poorer Temporal-Spatial Performance Measures.Frontiers in physiology · 2021Article
- Early Development of Locomotor Patterns and Motor Control in Very Young Children at High Risk of Cerebral Palsy, a Longitudinal Case Series.Frontiers in human neuroscience · 2021Article
- Clinical Relevance of State-of-the-Art Analysis of Surface Electromyography in Cerebral Palsy.Frontiers in neurology · 2020Review
- Maturation of the Locomotor Circuitry in Children With Cerebral Palsy.Frontiers in bioengineering and biotechnology · 2020Review
- Muscle weakness has a limited effect on motor control of gait in Duchenne muscular dystrophy.PloS one · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo determine whether patient-specific differences in motor control quantified using muscle synergy analysis were associated with changes in gait after treatment of cerebral palsy (CP) across 2 clinical centers with different treatments and clinical protocols.
designRetrospective cohort study.
settingClinical medical center.
participantsCenter 1: children with CP (n=473) and typically developing (TD) children (n=84). Center 2: children with CP (n=163) and TD children (n=12).
interventionsStandard clinical care at each center.
main outcome measuresThe Dynamic Motor Control Index During Walking (walk-DMC) was computed from electromyographic data during gait using muscle synergy analysis. Regression analysis was used to evaluate whether pretreatment walking speed or kinematics, muscle synergies, treatment group, prior treatment, or age were associated with posttreatment changes in gait at both clinical centers.
resultsWalk-DMC was significantly associated with changes in speed and kinematics after treatment with similar regression models at both centers. Children with less impaired motor control were more likely to have improvements in walking speed and gait kinematics after treatment, independent of treatment group.
conclusionsDynamic motor control evaluated with synergy analysis was associated with changes in gait after treatment at both centers, despite differences in treatments and clinical protocols. This study further supports the finding that walk-DMC provides additional information, not captured in traditional gait analysis, that may be useful for treatment planning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.