Evidence map›Paper›PMID 29649366›Full record

ArticleJournal of dental research2018

FGF2 Enhances Odontoblast Differentiation by αSMA

I Vidovic-Zdrilic, K H Vining, A Vijaykumar, I Kalajzic, D J Mooney, M Mina

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

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  13. Amplifying Bone Marrow Progenitors Expressing α-Smooth Muscle Actin Produce Zonal Insertion Sites During Tendon-to-Bone Repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

I Vidovic-Zdrilic1 Departments of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, USA.
K H Vining2 John A. Paulson School of Engineering and Applied Sciences and Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-4009-879X
A Vijaykumar1 Departments of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, USA.
I Kalajzic3 Departments of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, USA.
D J Mooney2 John A. Paulson School of Engineering and Applied Sciences and Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.
M Mina1 Departments of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, USA.
UConn Health · USHarvard University · US

Funding

Analysis of GFP Transgenes in Odontoblast in DifferentiationR01DE016689 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MINA, MINA · 2006 to 2016
$3.3M
POLYMERIC MATRICES WITH DEFINED CELL ADHESION AND MECHANR01DE013033 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOONEY, DAVID J · 1998 to 2018
$3.0M
Anti-Inflammatory Mesenchymal Stem Cell Therapy for Dental ApplicationsK08DE025292 · NIDCR · HARVARD UNIVERSITY · PI VINING, KYLE HOLMBERG · 2016 to 2020
$635k
Skeletal, Craniofacial and Oral Biology Training GrantR90DE022526 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MINA, MINA · 2011 to 2022
$627k
NIDCR NIH HHS K08 DE025292NIDCR NIH HHS R01 DE016689NIDCR NIH HHS R90 DE022526
6 · The paper itself

Abstract

The goal of this study was to examine the effects of early and limited exposure of perivascular cells expressing α (αSMA) to fibroblast growth factor 2 (FGF2) in vivo. We performed in vivo fate mapping by inducible Cre-loxP and experimental pulp injury in molars to induce reparative dentinogenesis. Our results demonstrate that early delivery of exogenous FGF2 to exposed pulp led to proliferative expansion of αSMA-tdTomato

Indexed as

AnimalsCell DifferentiationDental PulpFibroblast Growth Factor 2Flow CytometryGene ExpressionIn Situ HybridizationMiceOdontoblastsFibroblast Growth Factor 2dentin matrix protein 1 (DMP1)dentin sialophosphoprotein (DSPP)perivascular cellspulp biologyreparative dentinogenesisstem cells

Identifiers

PMID29649366
PMCPMC6169028
OpenAlexW2796753248

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.