ArticlePLoS pathogens2018
Host shifts result in parallel genetic changes when viruses evolve in closely related species.
Article in PLoS pathogens, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Evolution of virulence of a plant RNA virus in developmental stage-structured host populations.Molecular biology and evolution · 2026Article
- A recurrent adaptive mutation in the transmembrane 2B protein of an insect picorna-like virus in a nonnative host.Journal of virology · 2026Article
- A Phylogenetic Host-Range Index Reveals Ecological Constraints in Phage Specialisation and Virulence.Molecular ecology · 2025Article
- Quantifying the strength of viral fitness trade-offs between hosts: a meta-analysis of pleiotropic fitness effects.Evolution letters · 2024Article
- Accurate Detection of Convergent Mutations in Large Protein Alignments With ConDor.Genome biology and evolution · 2024Article
- Investigating the outcomes of virus coinfection within and across host species.PLoS pathogens · 2023Article
- Heterogeneities in infection outcomes across species: sex and tissue differences in virus susceptibility.Peer community journal · 2023Article
- Hidden variable models reveal the effects of infection from changes in host survival.PLoS computational biology · 2023Article
- Viral spillover risk increases with climate change in High Arctic lake sediments.Proceedings. Biological sciences · 2022Article
- Developing an empirical model for spillover and emergence: Orsay virus host range inProceedings. Biological sciences · 2022Article
- Complete Genome Sequence, Molecular Characterization and Phylogenetic Relationships of a Novel Tern Atadenovirus.Microorganisms · 2021Article
- A New Double-Stranded RNA Mycovirus inJournal of fungi (Basel, Switzerland) · 2021Article
- Between virus correlations in the outcome of infection across host species: Evidence of virus by host species interactions.Evolution letters · 2021Article
- Viral susceptibility across host species is largely independent of dietary protein to carbohydrate ratios.Journal of evolutionary biology · 2021Article
- Article
- Distinct spread of DNA and RNA viruses among mammals amid prominent role of domestic species.Global ecology and biogeography : a journal of macroecology · 2020Article
- Virus evolution inProceedings. Biological sciences · 2019Article
- The phylogenomics of evolving virus virulence.Nature reviews. Genetics · 2018Review
- Changes in temperature alter the potential outcomes of virus host shifts.PLoS pathogens · 2018Article
- Mapping the Evolutionary Potential of RNA Viruses.Cell host & microbe · 2018Review
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Host shifts, where a pathogen invades and establishes in a new host species, are a major source of emerging infectious diseases. They frequently occur between related host species and often rely on the pathogen evolving adaptations that increase their fitness in the novel host species. To investigate genetic changes in novel hosts, we experimentally evolved replicate lineages of an RNA virus (Drosophila C Virus) in 19 different species of Drosophilidae and deep sequenced the viral genomes. We found a strong pattern of parallel evolution, where viral lineages from the same host were genetically more similar to each other than to lineages from other host species. When we compared viruses that had evolved in different host species, we found that parallel genetic changes were more likely to occur if the two host species were closely related. This suggests that when a virus adapts to one host it might also become better adapted to closely related host species. This may explain in part why host shifts tend to occur between related species, and may mean that when a new pathogen appears in a given species, closely related species may become vulnerable to the new disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.