ArticlePloS one2018
Do all infants need vitamin D supplementation?
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Sunlight exposure practice and its associated factors among infants in Ethiopia, systematic review and meta-analysis.PloS one · 2024Pooled it
- Pooled it
- Metagenomic analysis of the gut microbiome composition associated with vitamin D supplementation in Taiwanese infants.Scientific reports · 2021Trial
- Multilevel analysis of infant sunlight exposure practices among mothers in Mettu district Illubabor zone Oromia Ethiopia.Scientific reports · 2025Article
- Prevalence and determinants of insufficient vitamin D status in young Canadian Inuit children from Nunavik.Nutrition and health · 2025Article
- Practice and factors associated with neonatal sunlight exposure among mothers in Jigjiga City, Somali Regional State, Eastern Ethiopia.BMC pediatrics · 2025Article
- Mothers Practices and Factors Affecting Sunlight Exposure of Their Infants in Adami Tulu Jido Kombolcha District, East Shoa Zone, Oromia Region, Ethiopia, 2022: A Community Based Cross-Sectional Study.Global pediatric health · 2024Article
- Knowledge and practice of infant exposure to sunlight among mothers in the rural villages of Mettu district, southwest Ethiopia.Frontiers in public health · 2023Article
- Different Vitamin D Supplementation Strategies in the First Years of Life: A Systematic Review.Healthcare (Basel, Switzerland) · 2022Review
- Assessment of Practice and Factors associated with Sunlight Exposure of Infants among Mothers in Debre Berhan Town, North Shewa Zone, Amhara Region, Ethiopia.Pediatric health, medicine and therapeutics · 2021Article
- Knowledge and Practice of Infants Exposure to Sunlight Among Lactating Mothers Attending at Yirgalem Hospital, Sidama Regional State.Clinical medicine insights. Pediatrics · 2021Article
- Article
- The Approach to Tetanic Hypocalcemia Caused by Vitamin D Deficiency.Current health sciences journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A high prevalence of vitamin D deficiency (VDD) in children has been observed worldwide, but there are few studies on the nutritional status of vitamin D (VD) in healthy infants. The main cause of deficiency in healthy children is breastfeeding without supplementation and lack or insufficiency of sun exposure. The aims of this study were to determine serum concentrations of 25(OH)D and verify its association with parathyroid hormone (PTH) concentrations and use of VD supplementation in healthy infants aged ≥ 6 to ≤ 24 months attended at two Primary Health Care Units in Ribeirão Preto city, São Paulo, Brazil. A cross-sectional, observational and analytical study was performed in which serum concentrations of 25(OH)D, PTH, alkaline phosphatase (AP), calcium (Ca), phosphorus (P) and albumin were determined in 155 healthy infants. Information on sun exposure, sociodemographic aspects of mothers and clinical and nutritional characteristics of infants were obtained through interviews with responsible infants's legal representatives. Ten infants (6%) presented deficient 25(OH)D serum concentration (≤20ng/ml) and 46 (30%), insufficient (21 to 29ng/ml). No changes in serum P, Ca and albumin concentrations were detected. Only one infant had an increase in PTH serum concentrations. 35% (55/155) of infants had high AP e 40% (22/55) presented insufficient serum concentrations of 25(OH)D but none presented deficient ones. There was a weak association between serum concentrations of 25(OH)D and PTH and an association between serum concentrations of 25(OH)D and P when adjusted for sex, age and BMI. There were no associations between inadequate serum concentrations of 25(OH)D (deficient ou insufficient), sun exposure and VD supplementation. This study found a low prevalence of deficient 25(OH)D serum concentration and high prevalence of insufficient ones which was not associated with changes in serum PTH, AP, P, Ca and albumin concentrations, VD supplementation and the formula volume intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.