Evidence map›Paper›PMID 29649236›Full record

ArticlePloS one2018

Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration.

Matthias W Lorenz, Lu Gao, Kathrin Ziegelbauer, Giuseppe Danilo Norata, Jean Philippe Empana, Irene Schmidtmann, Hung-Ju Lin, Stela McLachlan, Lena Bokemark, Kimmo Ronkainen and 72 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Article
  8. Association Between Carotid Intima-Media Thickness and Novel Lipid Parameters in Hypertensive Patients.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025
    Article
  9. Article
  10. Vascular ageing: moving from bench towards bedside.European journal of preventive cardiology · 2023
    Article
  11. Article
  12. Article
  13. Aging of the Arterial System.International journal of molecular sciences · 2023
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Progress of Clinical Evaluation for Vascular Aging in Humans.Journal of translational internal medicine · 2021
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

82 authors at 20 institutions in 17 countries.

Matthias W LorenzDepartment of Neurology, Goethe University, Frankfurt am Main, Germany.ORCID 0000-0002-7565-1751
Lu GaoMRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, United Kingdom.
Kathrin ZiegelbauerDepartment of Neurology, Goethe University, Frankfurt am Main, Germany.
Giuseppe Danilo NorataDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milano, Italy.
Jean Philippe EmpanaParis Cardiovascular Research Centre (PARCC), University Paris Descartes, Sorbonne Paris Cité, UMR, Paris, France.
Irene SchmidtmannInstitut fuer Medizinische Biometrie, Epidemiologie und Informatik (IMBEI), Universitaetsmedizin Mainz, Mainz, Germany.
Hung-Ju LinDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Stela McLachlanUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom.
Lena BokemarkWallenberg Laboratory for Cardiovascular Research, Institution for Medicin, Department for Molecular and Clinical Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
Kimmo RonkainenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Mauro AmatoCentro Cardiologico Monzino, IRCCS, Milano, Italy.
Ulf SchminkeDepartment of Neurology, Greifswald University Clinic, Greifswald, Germany.
Sathanur R SrinivasanCenter for Cardiovascular Health, Department of Epidemiology, Biochemistry, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America.
Lars LindDepartment of Medicine, Uppsala University, Uppsala, Sweden.
Shuhei OkazakiDepartment of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan.
Coen D A StehouwerDepartment of Internal Medicine and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, the Netherlands.
Peter WilleitDepartment of Neurology, Medical University Innsbruck, Innsbruck, Austria.
Joseph F PolakTufts University School of Medicine, Tufts Medical Center, Boston, Massachusetts, United States of America.
Helmuth SteinmetzDepartment of Neurology, Goethe University, Frankfurt am Main, Germany.
Dirk SanderDepartment of Neurology, Benedictus Hospital Tutzing & Feldafing, Feldafing, Germany.
Holger PoppertDepartment of Neurology, Technische Universität München, Munich, Germany.
Moise DesvarieuxDepartment of Epidemiology,Mailman School of Public Health,Columbia University, New York, United States of America.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Stein Harald JohnsenDepartment of Clinical Medicine, Uit The Arctic University of Norway, Tromsø, Norway.
Daniel StaubDepartment of Angiology, University Hospital Basel, Basel, Switzerland.
Cesare R SirtoriCenter of Dyslipidemias, Niguarda Ca' Granda Hospital, Milano, Italy.
Bernhard IglsederParcelsus Medical University, Salzburg, Austria.
Oscar BeloquiDepartment of Internal Medicine, University Clinic of Navarra, Navarra, Spain.
Gunnar EngströmDepartment of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
Alfonso FrieraRadiology Department, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
Francesco RozzaSchool of Medicine, Federico II University, Naples, Italy.
Wuxiang XieDepartment of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases,Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Grace ParragaRobarts Research Institute, Western University, London, Ontario, Canada.
Liliana GrigoreCentro Sisa per lo Studio della Aterosclerosi, Bassini Hospital, Cinisello Balsamo, Italy.
Matthieu PlichartAssistance Publique, Hôpitaux de Paris, Hôpital Broca, Paris, France.
Stefan Blankenberg2nd Department of Medicine, Johannes Gutenberg-Universität, Mainz, Germany.
Ta-Chen SuDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Caroline SchmidtWallenberg Laboratory for Cardiovascular Research, University of Gothenburg, Gothenburg, Sweden.
Tomi-Pekka TuomainenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Fabrizio VegliaCentro Cardiologico Monzino, IRCCS, Milano, Italy.
Henry VölzkeGerman Center for Cardiovascular Research (DZHK),partner site Greifswald, Greifswald, Germany.
Giel NijpelsDepartment of General Practice, VU University Medical Center, Amsterdam, the Netherlands.
Johann WilleitDepartment of Neurology, Medical University Innsbruck, Innsbruck, Austria.
Ralph L SaccoDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.
Oscar H FrancoDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Heiko UthoffDepartment of Angiology, University Hospital Basel, Basel, Switzerland.
Bo HedbladDepartment of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
Carmen SuarezInternal Medicine Department, Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
Raffaele IzzoSchool of Medicine, Federico II University, Naples, Italy.
Dong ZhaoDepartment of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases,Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Thapat WannarongStroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Ontario, Canada.
Alberico CatapanoIRCSS Multimedica, Milan, Italy.
Pierre DucimetiereUniversity Paris_Sud Xi, Kremlin-Bicêtre, Le Kremlin-Bicêtre, France.
Christine Espinola-Klein2nd Department of Medicine, Johannes-Gutenberg University, Mainz, Germany.
Kuo-Liong ChienInstitute of Epidemiology and Preventive Medicine, College of Public Health,National Taiwan University, Taipei, Taiwan.
Jackie F PriceUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom.
Göran BergströmWallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy, Gothenburg University, Götheborg, Sweden.
Jussi KauhanenInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Elena TremoliDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milano, Italy.
Marcus DörrDepartment B for Internal Medicine, University Medicine Greifswald, Greifswald, Germany.
Gerald BerensonDepartment of Medicine, Pediatrics, Biochemistry, Epidemiology, Tulane University School of Medicine and School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States of America.
Kazuo KitagawaDepartment of Neurology, Tokyo Women's Medical University, Tokyo, Japan.
Jacqueline M DekkerDepartment of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, the Netherlands.
Stefan KiechlDepartment of Neurology, Medical University Innsbruck, Innsbruck, Austria.
Matthias SitzerDepartment of Neuology, Klinikum Herford, Herford, Germany.
Horst BickelDepartment of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany.
Tatjana RundekDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.
Albert HofmanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Ellisiv B MathiesenDepartment of Clinical Medicine, Uit The Arctic University of Norway, Tromsø, Norway.
Samuela CastelnuovoCenter of Dyslipidemias, Niguarda Ca' Granda Hospital, Milano, Italy.
Manuel F LandechoDepartment of Internal Medicine, University Clinic of Navarra, Navarra, Spain.
Maria RosvallDepartment of Clinical Sciences in Malmö, Lund University, Malmö, Sweden.
Rafael GabrielEscuela National de Sanidad, Instituto de Salud Carlos III, Madrid, Spain.
Nicola de LucaSchool of Medicine, Federico II University, Naples, Italy.
Jing LiuDepartment of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases,Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Damiano BaldassarreDepartment of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milano, Italy.
Maryam KavousiDepartment of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, the Netherlands.
Eric de GrootImagelabonline & Cardiovascular, Eindhoven and Lunteren, the Netherlands.
Michiel L BotsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
David N YanezDepartment of Biostatistics, University of Washington, Seattle, Washington, United States of America.
Simon G ThompsonDepartment of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
PROG-IMT study group
Erasmus MC · NLUniversity of Milan · ITCapital Medical University · CNFederico II University Hospital · ITGoethe University Frankfurt · DEInnsbruck Medical University · ATLund University · SEUniversitätsmedizin Greifswald · DEUniversity of Eastern Finland · FIAmsterdam Public Health · NLAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITCentro Cardiologico Monzino · ITClinica Universidad de Navarra · ESJohannes Gutenberg University Mainz · DENational Taiwan University Hospital · TWTechnical University of Munich · DETulane University · USUniversidad Autónoma de Madrid · ESUniversity Hospital of Basel · CHUniversity of Edinburgh · GB

Funding

ORAL INFECTIONS, CAROTID ATHEROSCLEROSIS AND STROKER01DE013094 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DESVARIEUX, MOISE · 2000 to 2016
$14.4M
Stroke Incidence and Risk Factors in a Tri-Ethnic RegionR37NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 2008 to 2014
$12.1M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHS Events Follow-up StudyR01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2009 to 2014
$6.3M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
Predictors of Alheimers Disease in Mild Cognitive ImpairmentR01AG020098 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 2002 to 2011
$3.7M
Hormonal trajectories in agingR01AG027058 · NIA · UNIVERSITY OF PENNSYLVANIA · PI CAPPOLA, ANNE R · 2006 to 2009
$1.2M
Genetics Determinants of Extreme Phenotypes of Subclinical AtherosclerosisK24NS062737 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI RUNDEK, TATJANA · 2009 to 2013
$975k
Predictors of Alzheimers Disease in Mild Cognitive ImpairmentR56AG020098 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 2007 to 2007
$482k
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R56AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2010 to 2010
$300k
CHS-ULTRASOUND READINGN01HC045133 · HC · GEISINGER HEALTH SYSTEM · PI O'LEARY, DANIEL H. · 1994 to 2000
$155k
CARDIOVASCULAR HEALTH STUDY-ECHOCARDIOGRAPHY READING CTRN01HC035129 · HC · GEORGETOWN UNIVERSITY · PI GOTTDIENER, JOHN S. · 1993 to 2001
–
British Heart Foundation RG/13/13/30194Medical Research Council MR/L003120/1NHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL080295NHLBI NIH HHS U01 HL080295NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG027058NIA NIH HHS R56 AG020098NIA NIH HHS R56 AG023629NIDCR NIH HHS R01 DE013094NINDS NIH HHS K24 NS062737NINDS NIH HHS R37 NS029993
6 · The paper itself

Abstract

aimsCarotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. METHODS AND

resultsFrom 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C.

conclusionsWe confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.

Indexed as

Carotid Intima-Media ThicknessIntersectoral CollaborationAgedCardiovascular DiseasesFemaleHumansMaleMiddle AgedPrognosisRisk Factors

Identifiers

PMID29649236
PMCPMC5896895
OpenAlexW2797361465

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.