GuidelineMMWR. Morbidity and mortality weekly report2018
Updated CDC Recommendations for Using Artemether-Lumefantrine for the Treatment of Uncomplicated Malaria in Pregnant Women in the United States.
Guideline in MMWR. Morbidity and mortality weekly report, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05757167 (Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity), which is not on this map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity
Who cites it
14 citing papers in PubMed.
- Current update on malaria in pregnancy: a systematic review.Tropical diseases, travel medicine and vaccines · 2025Review
- From Traditional Use to Modern Evidence: The Medicinal Chemistry of Antimalarials from GenusMini reviews in medicinal chemistry · 2025Review
- Malaria Surveillance - United States, 2018.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2022Article
- Review
- Malaria Surveillance - United States, 2017.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2021Article
- Drug treatment and prevention of malaria in pregnancy: a critical review of the guidelines.Malaria journal · 2021Review
- Research Advances on Health Effects of EdibleFoods (Basel, Switzerland) · 2020Review
- Diagnosis & management of imported malaria in pregnant women in non-endemic countries.The Indian journal of medical research · 2020Review
- Safety of Artemisinin Derivatives in the First Trimester of Pregnancy: A Controversial Story.Molecules (Basel, Switzerland) · 2020Review
- Malaria in the pregnant traveler.Journal of travel medicine · 2020Article
- Management of Travel-Related Infectious Diseases in the Emergency Department.Current emergency and hospital medicine reports · 2020Review
- Malaria in Pregnancy: What the Obstetric Provider in Nonendemic Areas Needs to Know.Obstetrical & gynecological survey · 2019Review
- Malaria Surveillance - United States, 2015.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2018Article
- An update on prevention of malaria in travelers.Therapeutic advances in infectious diseaseReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malaria infection during pregnancy is associated with an increased risk for maternal and fetal complications. In the United States, treatment options for uncomplicated, chloroquine-resistant Plasmodium falciparum and P. vivax malaria in pregnant women are limited to mefloquine or quinine plus clindamycin (1). However, limited availability of quinine and increasing resistance to mefloquine restrict these options. Strong evidence now demonstrates that artemether-lumefantrine (AL) (Coartem) is effective and safe in the treatment of malaria in pregnancy. The World Health Organization (WHO) has endorsed artemisinin-based combination therapies (ACTs), such as AL, for treatment of uncomplicated malaria during the second and third trimesters of pregnancy and is currently considering whether to add ACTs, including AL, as an option for malaria treatment during the first trimester (2,3). This policy note reviews the evidence and updates CDC recommendations to include AL as a treatment option for uncomplicated malaria during the second and third trimesters of pregnancy and during the first trimester of pregnancy when other treatment options are unavailable. These updated recommendations reflect current evidence and are consistent with WHO treatment guidelines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.