SynthesisNutrients2018
Vitamin D Deficiency and Antenatal and Postpartum Depression: A Systematic Review.
Synthesis in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- A Systematic Review of the Correlation Between Micronutrient Levels and Perinatal Depression.Nutrients · 2025Pooled it
- Risk factors for postpartum depression: an umbrella review.Frontiers in public health · 2025Pooled it
- Pooled it
- Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases-An Umbrella Review.Nutrients · 2020Pooled it
- Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial.BMC psychiatry · 2022Trial
- Effects of vitamin D on insulin resistance and fasting blood glucose in pregnant women with insufficient or deficient vitamin D: a randomized, placebo-controlled trial.BMC endocrine disorders · 2022Trial
- Pregnancy Vitamin D Deficiency Prevalence and Adverse Birth Outcomes in Mazandaran, a Province of Iran: A Cross-Sectional Study.Journal of pregnancy · 2026Article
- Association between first-trimester serum 25(OH)D and EPDS-positive postpartum depressive symptoms in women with gestational diabetes mellitus: a retrospective cohort study.Frontiers in psychiatry · 2026Article
- Bad times make mothers depressed.International journal of health economics and management · 2025Article
- Vitamin D Deficiency During Pregnancy Is Associated with Postpartum Depression: A Cohort Study in Southern Brazil.Nutrients · 2025Article
- Optimal serum vitamin D3 levels are associated with lower osteoarthritis risk and better overall health in US adults.Scientific reports · 2025Article
- Loneliness, insomnia symptoms, social jetlag, and vitamin D deficiency in relation to mental health problems in Japanese female university students: a cross-sectional study.Journal of physiological anthropology · 2025Article
- Relationship Between Vitamin D Deficiency and Postpartum Depression.Journal of personalized medicine · 2025Review
- Plasma vitamin D binding protein as the potential predictor of depressive disorder risk in breast cancer patients.Scientific reports · 2025Article
- The immune checkpoint pathophysiology of depression and chronic fatigue syndrome due to preeclampsia: focus on sCD80 and sCTLA-4.Acta neuropsychiatrica · 2025Article
- Husband involvement in antenatal care moderates the link between vitamin D status and depressive symptoms in pregnant women.Epidemiology and psychiatric sciences · 2025Article
- A longitudinal network analysis of interaction factors among Chinese women at high risk for perinatal depression.Midwifery · 2024Article
- Associations Between Early-Pregnancy Vitamin D Status and Postpartum Depressive and Anxiety Symptoms.Psychosomatic medicine · 2024Article
- Antenatal Depression and its Associated Factors: Findings from Kuwait Birth Cohort Study.Journal of epidemiology and global health · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D has been implicated in antenatal depression (AD) and postpartum depression (PPD) in many studies; however, results have been inconsistent due to the complexity of this association. We searched the MEDLINE, Embase, PsycINFO, and Maternity and Infant Care databases for literature addressing associations between vitamin D and AD and PPD. Two independent authors reviewed titles and abstracts of the search results and selected studies for full review. Data were extracted, and a quality rating was done using the Newcastle-Ottawa Scale (NOS) on the selected studies. A total of 239 studies were identified; 14 were included in the review. The quality assessment of the included studies ranged from moderate to high. Of the studies on PPD, five of nine (55%) showed a significant association between vitamin D and PPD. Five of seven (71%) studies on AD showed a significant association with vitamin D status. As the included studies used different effect estimates and statistical analyses to report the association, it was not possible to transform the existing data into one single effect measure to employ meta-analytic techniques. While results of this systematic review vary, they indicate a significant association between vitamin D status and AD and PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.