Evidence map›Paper›PMID 29649107›Full record

ArticleNutrients2018

Impaired Hematologic Status in Relation to Clinical Outcomes among HIV-Infected Adults from Uganda: A Prospective Cohort Study.

Amara E Ezeamama, David Guwatudde, Alla Sikorskii, Edmond K Kabagambe, Raybun Spelts, Grace Vahey, Jenifer I Fenton, Wafaie W Fawzi

Abstract read
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Anemia, Iron Status, and HIV: A Systematic Review of the Evidence.Advances in nutrition (Bethesda, Md.) · 2020
    Pooled it
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  3. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amara E EzeamamaDepartment of Psychiatry, College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA. amara.ezeamama@hc.msu.edu.
David GuwatuddeSchool of Public Health, Makerere University College of Health Sciences, Kampala, Uganda. dguwatudde@gmail.com.
Alla SikorskiiDepartment of Psychiatry, College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA. Alla.Sikorskii@hc.msu.edu.
Edmond K KabagambeDivision of Epidemiology, Department of Medicine Vanderbilt University Medical Center, Nashville, TN 37203, USA. edmond.kabagambe@vanderbilt.edu.
Raybun SpeltsCollege of Public Health, University of Georgia, Athens, GA 30602, USA. raybun2012@gmail.com.
Grace VaheyCollege of Public Health, University of Georgia, Athens, GA 30602, USA. grace.vahey@gmail.com.
Jenifer I FentonDepartment of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA. imigjeni@anr.msu.edu.
Wafaie W FawziDepartments of Global Health and Population, Nutrition and Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA. mina@hsph.harvard.edu.

Funding

Multi-vitamins, HAART and HIV/AIDS in UgandaR01HD060333 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI FAWZI, WAFAIE W · 2008 to 2012
$1.6M
NICHD NIH HHS R01 HD060333
6 · The paper itself

Abstract

Impaired hematologic status (IHS) was investigated as a determinant of immune function defined as cluster of differentiation 4 (CD4) T-helper cell count, quality of life (QOL) weight and hospitalization/mortality over 18-months among 398 adult persons living with HIV/AIDS (PLWHA) on anti-retroviral therapy. IHS was defined as having anemia at baseline (Hemoglobin: <12 g/dL for women and <13 g/dL for men), time-updated anemia or having low (<30 μg/L) or high (>200 μg/L for men and >150 μg/L for women) ferritin levels at baseline. Months-to-hospitalization/death or study-end (if no event) was calculated from enrollment. Multivariable linear-mixed models quantified associations between IHS and changes in CD4 cell-count, weight gain and QOL. Cox proportional hazards models calculated hazard ratios (HR) and corresponding 95% confidence intervals (CI) for IHS-related differences in time-to-hospitalization/death. The prevalences of anemia and high and low ferritin levels at baseline were 48.7% (

Indexed as

AdolescentAdultAnemiaAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBiomarkersBody Mass IndexCD4 Lymphocyte CountFemaleFerritinsHemoglobinsHIV InfectionsHumansIronLinear ModelsLongitudinal StudiesAnti-HIV AgentsBiomarkersFerritinsHemoglobinsIronanemiaanemia persistenceclinical outcomesferritinHIViron status

Identifiers

PMID29649107
PMCPMC5946260

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.