Evidence map›Paper›PMID 29649078›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2018

Point of Diagnosis and Patient Retention in HIV Care in Western Kenya.

Becky L Genberg, Hana Lee, Joseph W Hogan, Fatma Some, Juddy Wachira, Xiaotian K Wu, Paula Braitstein

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Becky L GenbergDepartment of Health Services, Policy and Practice, Brown University, Providence, RI.
Hana LeeDepartment of Biostatistics, Brown University, Providence, RI.
Joseph W HoganDepartment of Biostatistics, Brown University, Providence, RI.
Fatma SomeAcademic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.
Juddy WachiraAcademic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.
Xiaotian K WuDepartment of Biostatistics, Brown University, Providence, RI.
Paula BraitsteinAcademic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.
Brown University · USMoi University · KEAMPATH · KEUniversity of Toronto · CA

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
Science/Technical CoreP2CHD041020 · NICHD · BROWN UNIVERSITY · PI ZHENCHAO QIAN · 2016 to 2026
$7.6M
Optimizing HIV Treatment Monitoring under Resource ConstraintsR01AI108441 · NIAID · BROWN UNIVERSITY · PI HOGAN, JOSEPH W, KANTOR, RAMI · 2015 to 2019
$3.5M
Linkage to Care Following Home-Based Counseling and Testing in Western KenyaK01MH099966 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GENBERG, BECKY LYNN · 2013 to 2017
$826k
NIAID NIH HHS P30 AI042853NIAID NIH HHS R01 AI108441NICHD NIH HHS P2C HD041020NIMH NIH HHS K01 MH099966PEPFAR
6 · The paper itself

Abstract

backgroundHome-based counseling and testing (HBCT) achieves earlier HIV diagnosis than other testing modalities; however, retention in care for these healthier patients is unknown. The objective of this study was to determine the association between point of HIV testing and retention in care and mortality.

settingAcademic Model Providing Access to Healthcare (AMPATH) has provided HIV care in western Kenya since 2001.

methodsAMPATH initiated HBCT in 2007. This retrospective analysis included individuals 13 years and older, enrolled in care between January 2008 and September 2016, with data on point of testing. Discrete-time multistate models were used to estimate the probability of transition between the following states: engaged, disengaged, transfer, and death, and the association between point of diagnosis and transition probabilities.

resultsAmong 77,358 patients, 67% women, median age: 35 years and median baseline CD4: 248 cells/mm. Adjusted results demonstrated that patients from HBCT were less likely to disengage [relative risk ratio (RRR) = 0.87, 95% CI: 0.83 to 0.91] and die (RRR = 0.65, 95% CI: 0.55 to 0.75), whereas those diagnosed through provider-initiated counseling and testing were more likely to disengage (RRR = 1.09, 95% CI: 1.07 to 1.12) and die (RRR = 1.13, 95% CI: 1.06 to 1.20), compared with patients from voluntary counseling and testing. Once disengaged, patients from HBCT were less likely to remain disengaged, compared with patients from voluntary counseling and testing.

conclusionsPatients entering care from different HIV-testing programs demonstrate differences in retention in HIV care over time beyond disease severity. Additional research is needed to understand the patient and system level factors that may explain the associations between testing program, retention, and mortality.

Indexed as

Drug MonitoringPoint-of-Care TestingAdolescentAdultAgedFemaleHIV InfectionsHumansKenyaMaleMiddle AgedRetrospective StudiesSurvival AnalysisYoung Adult

Identifiers

PMID29649078
PMCPMC6091686
OpenAlexW2798080521

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.