ArticleEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)2019
A case-control study of risk factors for colorectal cancer in an African population.
Article in European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Colorectal Cancer Risk Factors in Adults in Nigeria.JAMA network open · 2026Article
- Emerging trends in the global burden of colorectal cancer.Nature reviews. Clinical oncology · 2026Review
- Colorectal cancer incidence and survival trends in Uganda: a population-based registry analysis (2000-20).International journal of epidemiology · 2026Article
- Diabetes and socioeconomic status as key risk factors for colorectal cancer in the pashtun population: a case-control study.BMC gastroenterology · 2026Article
- Chronic Schistosomiasis Infection Dose not Affect the Prognosis of Gastric Cancer Patients.Journal of gastrointestinal cancer · 2026Article
- Secular trend of colorectal cancer related with low physical activity from 1990 to 2021 in China.BMC cancer · 2025Article
- Colorectal Cancer Risk and Protective Factors Among People of African Descent: A Systematic Review and Meta-Analysis.Cureus · 2025Review
- Predictive values of an immunological fecal occult blood test for the diagnosis of colorectal cancer compared using colonoscopy in symptomatic patients in Yaounde (Cameroon).BMC gastroenterology · 2024Article
- Colorectal Cancer Incidence in Iran Based on Sex, Age, and Geographical Regions: A Study of 2014-2017 and Projected Rates to 2025.Archives of Iranian medicine · 2024Article
- Colorectal cancer disease profile and treatment patterns at an urban tertiary hospital in Rwanda.Ecancermedicalscience · 2024Article
- Is the incidence rate of colorectal cancer increasing in Mozambique?Ecancermedicalscience · 2024Article
- Clinicopathological characteristics and its association with digestive system tumors of 1111 patients with Schistosomiasis japonica.Scientific reports · 2023Article
- Large Bowel Perforation in Patients with Colorectal Cancer: A South African Perspective.Journal of cancer & allied specialties · 2023Article
- Review
- Risk Factors for Colorectal Adenocarcinoma in an Indigenous Population in East Africa.Cancer management and research · 2022Article
- Urbanization Levels and Its Association with Prevalence of Risk Factors and Colorectal Cancer Incidence.Iranian journal of public health · 2021Article
- Association of Family History and Life Habits in the Development of Colorectal Cancer: A Matched Case-Control Study in Mexico.International journal of environmental research and public health · 2021Article
- Hereditary, environmental, and dietary risk factors of colorectal cancer: a case-control study in the Algerian East.Environmental science and pollution research international · 2021Article
- Spatiotemporal Trends of Colorectal Cancer Mortality Due to Low Physical Activity and High Body Mass Index From 1990 to 2019: A Global, Regional and National Analysis.Frontiers in medicine · 2021Article
- Cancer in Africa: The Untold Story.Frontiers in oncology · 2021Article
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Authors and funding
9 authors.
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Abstract
The interplay between hereditary and environmental factors in the causation of colorectal cancer in sub-Saharan Africa is poorly understood. We carried out a community based case-control study to identify the risk factors associated with colorectal cancer in Zimbabwe. We recruited 101 cases of colorectal cancer and 202 controls, matched for age, sex and domicile. Potential risk factors including family history, socioeconomic status, urbanization, diabetes mellitus and previous schistosomiasis were evaluated. Conditional logistic regression was used to estimate the odds ratios associated with the different factors. Cases were more likely to have a tertiary education (32.7 vs. 13.4%, P<0.001) and a higher income (18.8 vs. 6.9%, P=0.002). After multivariate analysis, diabetes mellitus [odds ratio (OR): 5.3; 95% confidence interval (CI): 1.4-19.9; P=0.012], previous urban domicile (OR: 2.8; 95% CI: 1.0-7.8; P=0.042), previous schistosomiasis (OR: 2.4; 95% CI: 1.4-4.2; P=0.001) and cancer in a first-degree relative (OR: 2.4; 95% CI: 1.2-4.8; P=0.018) were associated independently with colorectal cancer. Our findings suggest that family history, diabetes mellitus, previous schistosomiasis and approximation to a western lifestyle are the predominant associations with colorectal cancer in Africans. This offers opportunities for targeted prevention and hypothesis-driven research into the aetiology of colorectal cancer in this population.
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