Evidence map›Paper›PMID 29648999›Full record

ArticleJournal of pediatric endocrinology & metabolism : JPEM2018

Cord blood klotho levels are inversely associated with leptin in healthy Latino neonates at risk for obesity.

Janet M Wojcicki, Aric A Prather, Elissa Epel, Dan Wang, Dena B Dubal

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric endocrinology & metabolism : JPEM, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Janet M WojcickiDepartment of Pediatrics, University of California, 550 15th Street, 5th Floor, San Francisco, CA 94134-0136, USA.
Aric A PratherDepartment of Psychiatry, University of California, San Francisco, CA, USA.
Elissa EpelDepartment of Psychiatry, University of California, San Francisco, CA, USA.
Dan WangDepartment of Neurology, University of California, San Francisco, CA, USA.
Dena B DubalDepartment of Neurology, University of California, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

Klotho and Neurodegenerative DiseaseR01NS092918 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUBAL, DENA BOU · 2016 to 2020
$1.7M
NINDS NIH HHS R01 NS092918
6 · The paper itself

Abstract

backgroundKlotho serum levels reflect nutritional state in adults including obesity and anorexia. The relationship between cord blood klotho levels at birth and parameters of growth including anthropometrics are not known.

methodsWe evaluated the relationship between cord blood klotho, leptin and adipocyte hormones and infant, child and maternal anthropometrics and maternal depression in a cohort of 73 children. Non-parametric tests were used to assess differences between dichotomous and categorical predictors and klotho levels and Spearman's rank coefficients were used to assess the relationship between klotho levels and continuous predictors. A multivariable log transformed linear regression model was used to test for independent predictors of serum klotho levels.

resultsMean klotho levels were 2864.9±1409.7 (pg/mL) in cord blood and we found no relationship with infant sex, delivery specifics including gestational age or anthropometrics at birth. There was similarly no association between klotho levels at birth and future obesity at age 2. Leptin levels at birth were inversely associated with klotho levels in multivariable models after adjusting for other covariates (p<0.01). Similarly, in multivariable models insulin levels were inversely correlated with klotho levels (p=0.03). Leptin levels in our cohort of at-risk infants were more than 50% higher than other studies with neonates.

conclusionsWe found no associations between weight or length at birth or obesity in early childhood and cord blood klotho levels. Cord blood klotho levels were inversely correlated with leptin and insulin levels at birth and should be further investigated to better understand the inter-relationship between this hormone and key regulators of growth and adiposity.

Indexed as

BiomarkersBody Mass IndexChild, PreschoolCohort StudiesFemaleFetal BloodGestational AgeGlucuronidaseHispanic or LatinoHumansInfantInfant, NewbornKlotho ProteinsLeptinMaleObesityBiomarkersGlucuronidaseKlotho ProteinsLeptingrowthklothoLatinoleptinneonate

Identifiers

PMID29648999
PMCPMC6770989
OpenAlexW2796611367

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.