Evidence map›Paper›PMID 29645346›Full record

ArticleJournal of leukocyte biology2018

Identification of a Siglec-F+ granulocyte-macrophage progenitor.

Jessica E Bolden, Erin C Lucas, Geyu Zhou, Jeremy A O'Sullivan, Carolyn A de Graaf, Mark D McKenzie, Ladina Di Rago, Tracey M Baldwin, Jake Shortt, Warren S Alexander and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of leukocyte biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Jessica E BoldenThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Erin C LucasThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Geyu ZhouThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Jeremy A O'SullivanDivision of Allergy and Immunology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Carolyn A de GraafThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Mark D McKenzieThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Ladina Di RagoThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Tracey M BaldwinThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Jake ShorttSchool of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Warren S AlexanderThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Bruce S BochnerDivision of Allergy and Immunology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Matthew E RitchieThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Douglas J HiltonThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Kirsten A FairfaxThe Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Walter and Eliza Hall Institute of Medical Research · AUUniversity of Melbourne · AUNorthwestern University · USMonash Health · AU

Funding

Treating lung inflammation by targeting SiglecsP01HL107151 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SCHNAAR, RONALD L · 2011 to 2017
$15.4M
Using siglecs and their ligands to treat allergic diseases SALTADU19AI136443 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHNAAR, RONALD L · 2018 to 2022
$7.6M
Northwestern University Allergy Immunology Research Program (NUAIR)T32AI083216 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Stephanie Caroline Eisenbarth, ADAM WILLIAMS · 2010 to 2026
$4.1M
Targeting Siglec-8/Siglec-F Reduce Allergic Responses In Vitro and In VivoR01AI072265 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BOCHNER, BRUCE S · 2007 to 2017
$3.9M
Targeting Siglec-8/-F to treat eosinophil and mast cell related disordersR56AI072265 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BOCHNER, BRUCE S · 2012 to 2012
$405k
NHLBI NIH HHS P01 HL107151NIAID NIH HHS R01 AI072265NIAID NIH HHS R56 AI072265NIAID NIH HHS T32 AI083216NIAID NIH HHS U19 AI136443
6 · The paper itself

Abstract

In recent years multi-parameter flow cytometry has enabled identification of cells at major stages in myeloid development; from pluripotent hematopoietic stem cells, through populations with increasingly limited developmental potential (common myeloid progenitors and granulocyte-macrophage progenitors), to terminally differentiated mature cells. Myeloid progenitors are heterogeneous, and the surface markers that define transition states from progenitors to mature cells are poorly characterized. Siglec-F is a surface glycoprotein frequently used in combination with IL-5 receptor alpha (IL5Rα) for the identification of murine eosinophils. Here, we describe a CD11b

Indexed as

AnimalsCell DifferentiationGranulocyte-Macrophage Progenitor CellsMiceMice, Inbred C57BLSialic Acid Binding Immunoglobulin-like LectinsSialic Acid Binding Immunoglobulin-like LectinseosinophilgranulocytehematopoiesisMybneutrophil

Identifiers

PMID29645346
PMCPMC6320667
OpenAlexW2802921724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.