ArticlePediatric surgery international2018
Neonatal independent predictors of severe NEC.
Article in Pediatric surgery international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A meta-analysis on the predictive role of CRP in NEC diagnosis and prognosis.Italian journal of pediatrics · 2025Pooled it
- Influencing factors for surgical treatment in neonatal necrotizing enterocolitis: a systematic review and meta-analysis.BMC pediatrics · 2024Pooled it
- Transfer learning prediction of surgical necrotizing enterocolitis in preterm infants without pneumoperitoneum on abdominal X-ray.Translational pediatrics · 2026Article
- Current operative approaches for necrotizing enterocolitis.World journal of pediatric surgery · 2026Review
- Gestational age-dependent clinical characteristics of necrotizing enterocolitis-associated intestinal perforation: a 10-year cohort study.BMC gastroenterology · 2025Article
- Fulminant necrotizing enterocolitis: clinical features and a predictive model.BMC pediatrics · 2025Article
- Article
- Value of portal venous gas and a nomogram for predicting severe neonatal necrotizing enterocolitis.Pediatric research · 2025Article
- Risk Factors and Outcome of Pneumatosis Intestinalis in Children.Children (Basel, Switzerland) · 2025Article
- Predictive value of biomarkers in neonatal necrotizing enterocolitis.Frontiers in pediatrics · 2025Review
- A time series algorithm to predict surgery in neonatal necrotizing enterocolitis.BMC medical informatics and decision making · 2024Article
- Neurodevelopmental impairment following surgical necrotizing enterocolitis with gestational age ≥ 28 weeks: who is at risk?Pediatric surgery international · 2024Article
- Novel scoring system for early diagnosis of necrotizing enterocolitis: integrating clinical and laboratory data with urinary caveolin-1 levels.Archives of medical science : AMS · 2024Article
- Laparotomy versus Peritoneal Drainage as Primary Treatment for Surgical Necrotizing Enterocolitis or Spontaneous Intestinal Perforation in Preterm Neonates: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2023Review
- Predictive value of serum markers in the operation evaluation of neonatal necrotizing enterocolitis.Translational pediatrics · 2023Article
- A Nomogram for Predicting Surgical Timing in Neonates with Necrotizing Enterocolitis.Journal of clinical medicine · 2023Article
- Noninvasive Fecal Cytokine and Microbiota Profiles Predict Commencement of Necrotizing Enterocolitis in a Proof-of-Concept Study.Gastro hep advances · 2023Article
- [Value of intestinal regional oxygen saturation and C-reactive protein in the diagnosis of necrotizing enterocolitis in preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Observational
- An improved joint non-negative matrix factorization for identifying surgical treatment timing of neonatal necrotizing enterocolitis.Bosnian journal of basic medical sciences · 2022Article
- Association between prognostic factors and the clinical deterioration of preterm neonates with necrotizing enterocolitis.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNecrotizing enterocolitis (NEC) is a severe neonatal disease. The present study aimed to identify factors predisposing the development of severe forms of NEC.
methodsThis retrospective study examined NEC patients in a single centre between 2002 and 2015. Data concerning clinical characteristics, therapeutic management as well as short-term outcomes were collected. We compared the patients receiving successful medical treatment and those requiring surgical intervention. Patients who underwent surgery were distinguished in three subcategories. Bivariate and multivariate analyses were used for the statistical analysis.
resultsWe identified 155 patients in the study period. 102 were treated conservatively and 53 required surgery. 8 received a primary peritoneal drainage, 31 received a drainage and a subsequent laparotomy and 14 received a laparotomy. Multivariate regression analysis identified a lower risk for surgery with a later onset and higher serum pH values, whereas an increased risk with higher C reactive Protein (CRP) levels at the onset. Pneumatosis intestinalis was identified as a protective factor. Overall mortality was 6.4%, with higher percentage in surgical NEC.
conclusionThis study suggests that a later onset is a protective sign for the progression to surgery, whereas lower pH values and higher CRP levels are prognostic factors associated with the need for surgery. The line of treatment involving explorative laparotomy in case of perforation seems to be rewarded by low morbidity and mortality rate.
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