Evidence map›Paper›PMID 29644451›Full record

ReviewCurrent oncology reports2018

Emerging Therapies in Metastatic Prostate Cancer.

Daniel W Sonnenburg, Alicia K Morgans

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current oncology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
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  12. Noncoding RNAs: potential regulators in cardioncology.American journal of physiology. Heart and circulatory physiology · 2019
    Review
  13. Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daniel W SonnenburgNorthwestern University Feinberg School of Medicine, Division of Hematology/Oncology and Robert H. Lurie Comprehensive Cancer Center, 676 N. St. Clair St., Chicago, IL, 60611, USA.
Alicia K MorgansNorthwestern University Feinberg School of Medicine, Division of Hematology/Oncology and Robert H. Lurie Comprehensive Cancer Center, 676 N. St. Clair St., Chicago, IL, 60611, USA. Alicia.morgans@northwestern.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewIn the last decade, there have been multiple landmark therapeutic advances for the treatment of metastatic prostate cancer, both in the castration-resistant and hormone-sensitive setting. In this review, we highlight recent progress and ongoing trials for metastatic prostate cancer, including advances in chemotherapy, androgen receptor-directed therapy, targeted therapies, and immunotherapy. RECENT

findingsSeveral landmark studies for men with metastatic hormone-sensitive prostate cancer demonstrated improvement in overall survival with the addition of docetaxel chemotherapy or abiraterone acetate to standard androgen deprivation therapy. A single-arm phase 2 study of the PARP inhibitor olaparib demonstrated high response rates and more favorable progression-free and overall survival for men with metastatic castration-resistant prostate cancer and DNA repair defects treated with olaparib compared with men without DNA repair defects. Multiple ongoing clinical trials are investigating novel hormonal therapies and combinations of chemotherapy, targeted small molecules, immunotherapy, and radiopharmaceuticals. Progress continues to be made in the treatment of metastatic prostate cancer, and ongoing clinical trials continue to investigate novel agents and approaches to treatment.

Indexed as

Drug TherapyHumansImmunotherapyMaleMolecular Targeted TherapyNeoplasm MetastasisProstatic NeoplasmsChemohormonal therapyHormonal therapyImmunotherapyMetastatic castration-resistant prostate CancerMetastatic hormone-sensitive prostate CancerRadiopharmaceuticalsTargeted small moleculesTargeting DNA repair defects

Identifiers

PMID29644451

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.