Evidence map›Paper›PMID 29644420›Full record

SynthesisInflammation research : official journal of the European Histamine Research Society ... [et al.]2018

Soluble TREM-1 as a predictive factor of neonatal sepsis: a meta-analysis.

Ioannis Bellos, Georgia Fitrou, Georgios Daskalakis, Nikolaos Thomakos, Nikolaos Papantoniou, Vasilios Pergialiotis

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. The potential role of heparin-binding protein in neonatal sepsis: research progress.Frontiers in cellular and infection microbiology · 2024
    Review
  12. Review
  13. Recent advances in neutrophil chemotaxis abnormalities during sepsis.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2022
    Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ioannis BellosSecond Department of Obstetrics and Gynecology, Attikon University Hospital, National and Kapodistrian University of Athens, 6, Danaidon str., 15232, Chalandri, Greece.
Georgia FitrouSecond Department of Obstetrics and Gynecology, Attikon University Hospital, National and Kapodistrian University of Athens, 6, Danaidon str., 15232, Chalandri, Greece.
Georgios DaskalakisFirst Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Nikolaos ThomakosSecond Department of Obstetrics and Gynecology, Attikon University Hospital, National and Kapodistrian University of Athens, 6, Danaidon str., 15232, Chalandri, Greece.
Nikolaos PapantoniouSecond Department of Obstetrics and Gynecology, Attikon University Hospital, National and Kapodistrian University of Athens, 6, Danaidon str., 15232, Chalandri, Greece.
Vasilios PergialiotisSecond Department of Obstetrics and Gynecology, Attikon University Hospital, National and Kapodistrian University of Athens, 6, Danaidon str., 15232, Chalandri, Greece. pergialiotis@yahoo.com.ORCID http://orcid.org/0000-0003-4510-1633

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe efficacy of soluble triggering receptor expressed on myeloid cell-1 (TREM-1) in detecting sepsis in adults has already been proven. To date, however, consensus in the field of neonatal sepsis is lacking. The purpose of the present systematic review is to accumulate current evidence in this field. SEARCH STRATEGY: We systematically searched Medline (1966-2017), Scopus (2004-2017), Clinicaltrials.gov (2008-2017), EMBASE (1980-2017), Cochrane Central Register of Controlled Trials CENTRAL (1999-2017) and Google Scholar (2004-2017) along with reference lists from included studies. MAIN

resultsEight studies were finally included in the present analysis, with a total number of 667 neonates. The estimated sensitivity for the summary point was 0.95 [95% CI (0.81-0.99)] and the specificity was 0.87 [95% CI (0.56-0.97)]. The diagnostic odds ratio was calculated at 132.49 [95% CI (6.85-2560.70)]. Fagan's nomogram demonstrated that the post-test probability increased to 71% and decreased to 2%, when the pre-test probability was set at 25%. However, significant discrepancy was observed in terms of the used cut-offs; therefore, the sensitivity and specificity presented in our meta-analysis should be reviewed with caution, as they may present an overestimation of the actual predictive efficacy of this protein.

conclusionCurrent evidence suggests that sTREM-1 may become a useful biomarker for the prediction of neonatal sepsis. However, the small number of studies and the variation of the threshold values limit its implementation in clinical practice. Future large-scale studies are needed to determine the optimal cut-off value that may discriminate normal levels from those suggestive of the presence of neonatal sepsis.

Indexed as

BiomarkersHumansInfant, NewbornNeonatal SepsisTriggering Receptor Expressed on Myeloid Cells-1BiomarkersTriggering Receptor Expressed on Myeloid Cells-1Meta-analysisNeonatal sepsisNewbornSepticSepticemiasTREM-1

Identifiers

PMID29644420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.