ArticleClinical kidney journal2018
Patterns of progression of chronic kidney disease at later stages.
Article in Clinical kidney journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Pooled it
- Association of Remnant Cholesterol Levels With Kidney Replacement Therapy Initiation in Korean Patients With Chronic Kidney Disease: A Prospective Cohort Study.Journal of lipid and atherosclerosis · 2026Article
- Diagnostic Performance of [Diagnostics (Basel, Switzerland) · 2026Article
- Explainable AI machine learning framework for chronic kidney disease prediction utilizing electronic health records.BMC medical informatics and decision making · 2026Review
- Heterogeneity of Estimated GFR Slopes According to Etiology, Estimated GFR and Urinary Albumin-to-Creatinine Ratio in a Large Cohort of Patients With CKD.Kidney international reports · 2026Article
- Clinical Profile and Determinants of Chronic Kidney Disease Progression in Patients With Cardiorenal Anaemia Syndrome in Tanzania: A Descriptive Post Hoc Prospective Observational Study.Health science reports · 2025Article
- Chronic kidney disease in the primary care setting: A narrative review.Journal of general and family medicine · 2025Review
- Quality of life in older immigrant adults on hemodialysis.PloS one · 2025Article
- Article
- Trajectories of kidney function and risk of mortality.International journal of epidemiology · 2023Article
- Risk of chronic kidney disease in patients with acute kidney injury following a major surgery: a US claims database analysis.Clinical kidney journal · 2023Article
- Costs Associated With Progression of Mildly Reduced Kidney Function Among Medicare Advantage Enrollees.Kidney medicine · 2023Article
- Article
- Using CUSUM in real time to signal clinically relevant decreases in estimated glomerular filtration rate.BMC nephrology · 2022Article
- Revisiting risk prediction tools for death and end-stage renal disease in older patients with advanced chronic kidney disease: a prospective study.International urology and nephrology · 2022Observational
- CKD Progression From the Time of Estimated GFR-Based Waitlist Eligibility and Racial Disparities in Transplant Access.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Article
- Influence of Nutrients on Kidney Diseases.Nutrients · 2022Article
- Design and Development of a Digital Counseling Program for Chronic Kidney Disease.Canadian journal of kidney health and disease · 2022Article
- Knowledge Requirements and Unmet Needs of Informal Caregivers of Patients with End-Stage Kidney Disease (ESKD) Receiving Haemodialysis: A Narrative Review.Healthcare (Basel, Switzerland) · 2021Review
- Different kidney function trajectory patterns before dialysis in elderly patients: clinical implications and outcomes.Renal failure · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAt later stages of chronic kidney disease (CKD), a pattern of linear and irreversible renal function decline is thought to be the most common. The objective of this study was to describe the characteristics of the different patterns of CKD progression, and to investigate potentially modifiable factors associated with the rate of decline of renal function.
methodsThis was a retrospective, observational study in a cohort of adult patients with CKD Stage 4 or 5 not on dialysis. Decline in renal function was estimated as the slope of the individual linear regression line of estimated glomerular filtration rate (eGFR) over time. The following patterns of CKD progression were considered: unidentifiable, linear, nonlinear (curvilinear) and positive (improvement of renal function).
resultsThe study group consisted of 915 patients (mean ±SD age 65 ± 14 years, 48% females, median follow-up time 16 months). A linear pattern was observed in 38%, unidentifiable in 23%, nonlinear in 24% and positive in 15% of the study patients. The mean eGFR slope was: -3.35 ± 4.45 mL/min/year. Linear and unidentifiable patterns were associated with more rapid loss of renal function. By multiple linear and logistic regression analysis, the magnitude of proteinuria, the systolic blood pressure and the treatment with dual renin-angiotensin system blockade were associated with more rapid CKD progression. On the contrary, older age and discontinuation of commonly prescribed medication with potential influence on renal function or eGFR measurements were associated with slower CKD progression.
conclusionsA majority of patients with advanced CKD show patterns of renal function decline different from linear, and several of the main determinants of CKD progression are potentially modifiable.
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