ArticleFrontiers in plant science2018
Moonlighting Proteins and Their Role in the Control of Signaling Microenvironments, as Exemplified by cGMP and Phytosulfokine Receptor 1 (PSKR1).
Article in Frontiers in plant science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Guanylate cyclase activity in moss: revisiting the role of ERECTA-like receptors.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Endogenous cAMP elevation inPlant signaling & behavior · 2024Article
- Phytosulfokine downregulates defense-related WRKY transcription factors and attenuates pathogen-associated molecular pattern-triggered immunity.The Plant journal : for cell and molecular biology · 2024Article
- Moonlighting Crypto-Enzymes and Domains as Ancient and Versatile Signaling Devices.International journal of molecular sciences · 2024Review
- Plant adenylate cyclases have come full circle.Nature plants · 2023Review
- Amino acid motifs for the identification of novel protein interactants.Computational and structural biotechnology journal · 2023Review
- New Horizons in Plant Cell Signaling.International journal of molecular sciences · 2022Article
- Modulation of Inflammatory Cytokine Production in Human Monocytes by cGMP and IRAK3.International journal of molecular sciences · 2022Article
- Moonlighting Proteins Shine New Light on Molecular Signaling Niches.International journal of molecular sciences · 2021Review
- Functional Crypto-Adenylate Cyclases Operate in Complex Plant Proteins.Frontiers in plant science · 2021Article
- Cross Talk Between Cyclic Nucleotides and Calcium Signaling Pathways in Plants-Achievements and Prospects.Frontiers in plant science · 2021Review
- IdentPMP: identification of moonlighting proteins in plants using sequence-based learning models.PeerJ · 2021Article
- Computational Identification of Functional Centers in Complex Proteins: A Step-by-Step Guide With Examples.Frontiers in bioinformatics · 2021Article
- Cyclic AMP: A Polyhedral Signalling Molecule in Plants.International journal of molecular sciences · 2020Review
- Multiple Forms of Multifunctional Proteins in Health and Disease.Frontiers in cell and developmental biology · 2020Review
- IRAK3 modulates downstream innate immune signalling through its guanylate cyclase activity.Scientific reports · 2019Article
- PlantMP: a database for moonlighting plant proteins.Database : the journal of biological databases and curation · 2019Article
- New Perspectives on Plant Adenylyl Cyclases.Frontiers in molecular biosciences · 2019Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signal generating and processing complexes and changes in concentrations of messenger molecules such as calcium ions and cyclic nucleotides develop gradients that have critical roles in relaying messages within cells. Cytoplasmic contents are densely packed, and in plant cells this is compounded by the restricted cytoplasmic space. To function in such crowded spaces, scaffold proteins have evolved to keep key enzymes in the correct place to ensure ordered spatial and temporal and stimulus-specific message generation. Hence, throughout the cytoplasm there are gradients of messenger molecules that influence signaling processes. However, it is only recently becoming apparent that specific complexes involving receptor molecules can generate multiple signal gradients and enriched microenvironments around the cytoplasmic domains of the receptor that regulate downstream signaling. Such gradients or signal circuits can involve moonlighting proteins, so called because they can enable fine-tune signal cascades via cryptic additional functions that are just being defined. This perspective focuses on how enigmatic activity of moonlighting proteins potentially contributes to regional intracellular microenvironments. For instance, the proteins associated with moonlighting proteins that generate cyclic nucleotides may be regulated by cyclic nucleotide binding directly or indirectly. In this perspective, we discuss how generation of cyclic nucleotide-enriched microenvironments can promote and regulate signaling events. As an example, we use the phytosulfokine receptor (PSKR1), discuss the function of its domains and their mutual interactions and argue that this complex architecture and function enhances tuning of signals in microenvironments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.