ArticleNature2018
Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size.
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Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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100citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
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100 citing papers in PubMed, 180 citations in OpenAlex.
- The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and development.Developmental biology · 2026Article
- Molecular signatures and lineage diversification of neurogenic and gliogenic radial glia in the gyrencephalic ferret cortex.Communications biology · 2026Article
- Advances in our understanding of distal progenitors in idiopathic pulmonary fibrosis: implications for novel therapeutics.The European respiratory journal · 2026Review
- Genomic approaches for understanding the evolution of the human brain.Nature neuroscience · 2026Review
- Primate abnormal spindle-like microcephaly-associated knockout causes severe microcephaly and oligodendrocyte loss in the brain.Protein & cell · 2026Article
- Human-specific lncRNAs contributed critically to human evolution by distinctly regulating gene expression.eLife · 2026Article
- Targeted gene transfer into developmentally defined cell populations of the primate brain.Cell reports · 2026Article
- Ferrets and genetically modified ferrets as model organisms in biomedical research: a review.Frontiers in genome editing · 2026Review
- Investigation of the mechanisms underlying the development and evolution of the mammalian cerebrum using gyrencephalic ferrets.Frontiers in cell and developmental biology · 2026Review
- Article
- Molecular signatures and lineage diversification of neurogenic and gliogenic radial glia in the gyrencephalic ferret cortex.Research square · 2025Article
- Isolation and Culture of Ferret Airway Stem Cells.Bio-protocol · 2025Article
- Developmental and tissue-specific roles of mammalian centrosomes.The FEBS journal · 2025Review
- An Overview of Anesthetic Procedures for Ferret (Mustela putorius furo) Preclinical Brain MRI: A Call for Standardization.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Review
- Reconstructing human-specific regulatory functions in model systems.Current opinion in genetics & development · 2024Review
- The Control of Cortical Folding: Multiple Mechanisms, Multiple Models.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion.Nature communications · 2024Article
- Gene regulatory landscape of cerebral cortex folding.Science advances · 2024Article
- Diet-induced obesity affects influenza disease severity and transmission dynamics in ferrets.Science advances · 2024Article
- Targeted blockade of aberrant sodium current in a stem cell-derived neuron model of SCN3A encephalopathy.Brain : a journal of neurology · 2024Article
40 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors at 8 institutions in 1 country.
Matthew B JohnsonDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Xingshen SunDepartment of Anatomy and Cell Biology, Center for Gene Therapy, University of Iowa, Iowa City, IA, USA.
Andrew KodaniDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Rebeca Borges-MonroyDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Kelly M GirskisDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Steven C RyuDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Peter P WangDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Komal PatelDepartment of Neurosurgery, School of Medicine, Yale University, New Haven, CT, USA.
Dilenny M GonzalezDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Yu Mi WooDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
Ziying YanDepartment of Anatomy and Cell Biology, Center for Gene Therapy, University of Iowa, Iowa City, IA, USA.
Bo LiangDepartment of Anatomy and Cell Biology, Center for Gene Therapy, University of Iowa, Iowa City, IA, USA.
Richard S SmithDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Manavi ChatterjeeDepartment of Neurosurgery, School of Medicine, Yale University, New Haven, CT, USA.
Daniel ComanMagnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA.
Xenophon PapademetrisQuantitative Neuroscience with Magnetic Resonance (QNMR) Core Center, Yale University, New Haven, CT, USA.
Lawrence H StaibDepartment of Radiology & Biomedical Imaging, Yale University, New Haven, CT, USA.
Fahmeed HyderMagnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA.
Joseph B MandevilleAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.
P Ellen GrantDivision of Newborn Medicine, Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Kiho ImDivision of Newborn Medicine, Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Hojoong KwakDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
John F EngelhardtDepartment of Anatomy and Cell Biology, Center for Gene Therapy, University of Iowa, Iowa City, IA, USA.
Christopher A WalshDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. christopher.walsh@childrens.harvard.edu.
Byoung-Il BaeDivision of Genetics and Genomics, Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. byoung-il.bae@yale.edu.
Yale University · USBoston Children's Hospital · USUniversity of Iowa · USHoward Hughes Medical Institute · USCornell University · USDana-Farber/Boston Children's Cancer and Blood Disorders Center · USHarvard University · USMassachusetts General Hospital · US
Funding
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5MCell Identity Determination In Human Brain: Somatic Mutation and Cell LineageR01NS032457 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Alice Eunjung Lee, Christopher A. Walsh · 1995 to 2026
$12.7MHUMAN EPILEPSY GENETICS--NEURONAL MIGRATION DISORDERSR01NS035129 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WALSH, CHRISTOPHER A. · 1997 to 2023
$9.5MNeurophysiologicP30NS052519 · NINDS · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2007 to 2017
$6.7MAdvanced Fetal ImagingR01EB017337 · NIBIB · BOSTON CHILDREN'S HOSPITAL · PI ADALSTEINSSON, ELFAR, GRANT, PATRICIA ELLEN · 2014 to 2018
$6.2MEnergetics of Neuronal Populations by fMRIR01MH067528 · NIMH · YALE UNIVERSITY · PI HYDER, DEWAN SYED FAHMEED · 2002 to 2021
$5.9MNational Ferret Resource and Research Center on Lung DiseaseR24HL123482 · NHLBI · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F · 2014 to 2018
$3.8MMulti-context software for robust and reproducible neuroscience image analysisR24MH114805 · NIMH · YALE UNIVERSITY · PI PAPADEMETRIS, XENOPHON, SCHEINOST, DUSTIN · 2017 to 2019
$1.2MSpatio-temporal Patterns of Early Cortical Folding in the Human Fetal BrainR21HD083956 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI IM, KIHO · 2016 to 2017
$487kMolecular control of brain sizeR21NS091865 · NINDS · YALE UNIVERSITY · PI BAE, BYOUNG-IL · 2015 to 2016
$473kRole for ion conducting proteins in cortical malformation diseasesK99NS112604 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI SMITH, RICHARD S · 2019 to 2021
$276kCerebral Cortex Malformations - Genetics and Physiological ValidationF32NS100338 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI SMITH, RICHARD S · 2017 to 2019
$161kHoward Hughes Medical InstituteNHLBI NIH HHS R24 HL123482NIBIB NIH HHS R01 EB017337NICHD NIH HHS R21 HD083956NIEHS NIH HHS P30 ES005605NIMH NIH HHS R01 MH067528NIMH NIH HHS R24 MH114805NINDS NIH HHS F32 NS100338NINDS NIH HHS K99 NS112604NINDS NIH HHS P30 NS052519NINDS NIH HHS R01 NS032457NINDS NIH HHS R01 NS035129NINDS NIH HHS R21 NS091865
Abstract
The human cerebral cortex is distinguished by its large size and abundant gyrification, or folding. However, the evolutionary mechanisms that drive cortical size and structure are unknown. Although genes that are essential for cortical developmental expansion have been identified from the genetics of human primary microcephaly (a disorder associated with reduced brain size and intellectual disability)
Indexed as
Biological EvolutionFerretsGene DeletionAmino Acid SequenceAnimalsCalmodulin-Binding ProteinsCentrosomeCerebral CortexDisease Models, AnimalFemaleGene EditingGene Expression Regulation, DevelopmentalGene Knockout TechniquesGerm-Line MutationHumansMaleASPM protein, mouseCalmodulin-Binding ProteinsNerve Tissue Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.