ArticleNature2018
An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Recessive Genome-Wide Meta-analysis Illuminates Genetic Architecture of Type 2 Diabetes.Diabetes · 2022Pooled it
- Stalled translation on transcripts cleaved by RNase L activates signaling important for innate immunity.RNA (New York, N.Y.) · 2026Article
- Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control.Nature structural & molecular biology · 2025Article
- Translational Control in Cardiac Pathophysiology and Therapeutic Development: When mRNA Meets the Heart.International journal of molecular sciences · 2025Review
- Pelota-mediated ribosome-associated quality control counteracts aging and age-associated pathologies across species.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- mRNA translational control of regeneration.Current opinion in genetics & development · 2025Review
- Lysyl-tRNA synthetase orchestrates translation and hormone signaling during reproduction in Aedes aegypti mosquitoes.Communications biology · 2025Article
- Emerging roles of ribosome translation in stem cells and stem cell therapy - a review.Cell & bioscience · 2025Review
- Dysregulated ribosome quality control in human diseases.The FEBS journal · 2025Review
- Practical Guide for Implementing Cryogenic Electron Microscopy Structure Determination in Dermatology Research.The Journal of investigative dermatology · 2025Review
- Caspase-8-dependent autophagy regulates neutrophil infiltration in oral squamous cell carcinoma.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil.Nucleic acids research · 2024Article
- Insect ribosome-rescuer Pelo-Hbs1 complex on sperm surface mediates paternal arbovirus transmission.Nature communications · 2024Article
- Ontogeny of Skin Stem Cells and Molecular Underpinnings.Current issues in molecular biology · 2024Review
- You had me at PELO: a "Ribosome Rescuer" induces NLR inflammasome assembly.Cellular & molecular immunology · 2024Article
- Ribosome biogenesis and function in development and disease.Development (Cambridge, England) · 2023Review
- Integration of human inspection and artificial intelligence-based morphological typing of patient-derived organoids reveals interpatient heterogeneity of colorectal cancer.Cancer science · 2022Article
- PELO facilitates PLK1-induced the ubiquitination and degradation of Smad4 and promotes the progression of prostate cancer.Oncogene · 2022Article
- Cytoplasmic RNA quality control failure engages mTORC1-mediated autoinflammatory disease.The Journal of clinical investigation · 2022Article
- Translational control of stem cell function.Nature reviews. Molecular cell biology · 2021Review
Corrections and comments
- Commented on by
Authors and funding
14 authors at 7 institutions in 4 countries.
Kifayathullah Liakath-AliCentre for Stem Cells and Regenerative Medicine, King's College London, London, UK.
Eric W MillsHoward Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Inês SequeiraCentre for Stem Cells and Regenerative Medicine, King's College London, London, UK.
Beate M LichtenbergerCentre for Stem Cells and Regenerative Medicine, King's College London, London, UK.
Angela Oliveira PiscoCentre for Stem Cells and Regenerative Medicine, King's College London, London, UK.
Kalle H SipiläCentre for Stem Cells and Regenerative Medicine, King's College London, London, UK.
Ajay MishraCentre for Stem Cells and Regenerative Medicine, King's College London, London, UK.
Harunori YoshikawaCentre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, UK.
Colin Chih-Chien WuHoward Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Tony LyCentre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, UK.
Angus I LamondCentre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, UK.
Ibrahim M AdhamInstitute of Human Genetics, University Medical Centre of Göttingen, Göttingen, Germany.
Rachel GreenHoward Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Fiona M WattCentre for Stem Cells and Regenerative Medicine, King's College London, London, UK. fiona.watt@kcl.ac.uk.
King's College London · GBHoward Hughes Medical Institute · USUniversity of Dundee · GBJohns Hopkins University · USMedical University of Vienna · ATUniversity of Edinburgh · GBUniversity of Göttingen · DE
Funding
Medical Research Council G0600796Wellcome Trust 206211/Z/17/Z
Abstract
Ribosome-associated mRNA quality control mechanisms ensure the fidelity of protein translation
Indexed as
Biological EvolutionHomeostasisAnimalsCell Cycle ProteinsCell DifferentiationCell ProliferationDisease ProgressionEndonucleasesEpidermal CellsEpidermisFemaleMaleMembrane GlycoproteinsMiceMicrofilament ProteinsMutationCell Cycle ProteinsEndonucleasesLgr5 protein, mouseLgr6 protein, mouseLrig1 protein, mouseMembrane GlycoproteinsMicrofilament ProteinsmTOR protein, mouseNerve Tissue ProteinsPelo protein, mouseReceptors, G-Protein-CoupledRNA, MessengerTOR Serine-Threonine Kinases
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.