Evidence map›Paper›PMID 29643443›Full record

ReviewNature reviews. Genetics2018

DNA methylation-based biomarkers and the epigenetic clock theory of ageing.

Steve Horvath, Kenneth Raj

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07404449 (Effects of Sex-Speciffic Compound Food Supplements on Changes in Biomarkers and Epigenetic Changes Associated With Longevity), which is not on this map. Cited by 1,776 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,776citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07404449 phase1active not recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Sex-Speciffic Compound Food Supplements on Changes in Biomarkers and Epigenetic Changes Associated With Longevity

TypeinterventionalSponsorUniversity of PrimorskaRan2026 to 2027Enrolled60ConditionsAgingArmscompound food supplements - female specific, compound food supplements - male specific, Placebo
3 · Its place in the literature

Who cites it

1,776 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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1,716 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Steve HorvathDepartment of Human Genetics, Gonda Research Center, David Geffen School of Medicine, Los Angeles, CA, USA. shorvath@mednet.ucla.edu.
Kenneth RajRadiation Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, UK.

Funding

The epiGenetIcs Leads to aGe-relAted diseases (GILGA-mesh) NetworkU34AG051425 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HORVATH, STEVE · 2015 to 2017
$954k
NIA NIH HHS U34 AG051425
6 · The paper itself

Abstract

Identifying and validating molecular targets of interventions that extend the human health span and lifespan has been difficult, as most clinical biomarkers are not sufficiently representative of the fundamental mechanisms of ageing to serve as their indicators. In a recent breakthrough, biomarkers of ageing based on DNA methylation data have enabled accurate age estimates for any tissue across the entire life course. These 'epigenetic clocks' link developmental and maintenance processes to biological ageing, giving rise to a unified theory of life course. Epigenetic biomarkers may help to address long-standing questions in many fields, including the central question: why do we age?

Indexed as

AgingAnimalsDNA MethylationEpigenesis, GeneticHumans

Identifiers

PMID29643443

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.