ArticleScientific reports2018
Toxicity of enrofloxacin, copper and their interactions on soil microbial populations and ammonia-oxidizing archaea and bacteria.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 28 citations in OpenAlex.
- Effects of sulfadiazine and Cu on soil potential nitrification and ammonia-oxidizing archaea and bacteria communities across different soils.Frontiers in microbiology · 2023Article
- Effects of antibiotics (enrofloxacin) on microbial community of water and sediment in an aquatic ecological model.Frontiers in veterinary science · 2023Article
- Antioxidant system alterations and biological health status of earthworms following long-term exposure to antibiotic-contaminated poultry litter.Environmental science and pollution research international · 2022Article
- Enrofloxacin-The Ruthless Killer of Eukaryotic Cells or the Last Hope in the Fight against Bacterial Infections?International journal of molecular sciences · 2022Review
- Response of ammonia-oxidizing archaea and bacteria to sulfadiazine and copper and their interaction in black soils.Environmental science and pollution research international · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enrofloxacin (EFX) is one of the most frequently used broad-spectrum veterinary drugs, and copper (Cu) is a heavy metal that could easily bind to certain antibiotic molecules. Hence EFX and Cu were chosen as representatives of antibiotics and heavy metals to explore the abundance and variation of soil microbial populations with a plate-counting technique, as well as the copy numbers of amoA gene in ammonia-oxidizing archaea (AOA) and ammonia-oxidizing bacteria (AOB) by quantitative PCR methods in Argosols samples. Treatments of applied EFX (0.05, 0.20, 0.80 mmol/kg), Cu (1.60 mmol/kg) and combined EFX and Cu (at molar ratios of 1:32,1:8,1:2) exhibited various effects on different soil microorganisms. The toxicity of combined EFX and Cu was more strongly expressed on both soil microbial populations and amoA gene (AOA and AOB) compared to the EFX treatment alone, in most cases, time and dose effects were observed. With respect to the amoA gene, the AOA-amoA gene was more abundant than the AOB-amoA gene, and the ratio ranged from ~8 to ~11. Moreover, the interaction types of EFX and Cu were more likely to be antagonistic (64.29%) than synergistic (35.71%) on soil abundance and function, which may be related to the incubation time and the ratio of EFX to Cu in the soil.
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