ArticleNature communications2018
Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Genotypic analysis of Plasmodium falciparum malaria parasites in a clinical trial of RTS,S vaccination in combination with seasonal malaria chemoprevention.Malaria journal · 2026Article
- Stage-aware transcriptomics reveals selective haplotype persistence in short-termbioRxiv : the preprint server for biology · 2026Article
- SIMPLseq: a high-sensitivity Plasmodium falciparum genotyping and PCR contamination tracking tool.Malaria journal · 2026Article
- Highly conserved Plasmodium vivax genomes in Duffy-negative individuals from Sudan.Scientific reports · 2025Article
- Stable Plasmodium falciparum merozoite surface protein-1 allelic diversity despite decreasing parasitaemia in children with multiple malaria infections.Malaria journal · 2025Article
- Distinct evolutionary regimes across domains of the Plasmodium falciparum CSP gene.Scientific reports · 2025Article
- Accumulation of Neutrophil Phagocytic Antibody Features Tracks With Naturally Acquired Immunity Against Malaria in Children.The Journal of infectious diseases · 2023Article
- Complexity of Plasmodium falciparum infection and genetic variations associated with differences in parasite clearance time in two Malian villages.Research square · 2023Article
- Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.Nature communications · 2023Article
- AmpSeqR: an R package for amplicon deep sequencing data analysis.F1000Research · 2023Article
- Whole Genome Sequencing Contributions and Challenges in Disease Reduction Focused on Malaria.Biology · 2022Review
- Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigens.PLoS computational biology · 2022Article
- Distinguishing gene flow between malaria parasite populations.PLoS genetics · 2021Article
- Both Coinfection and Superinfection Drive Complex Anaplasma marginale Strain Structure in a Natural Transmission Setting.Infection and immunity · 2021Article
- A newly characterized malaria antigen on erythrocyte and merozoite surfaces induces parasite inhibitory antibodies.The Journal of experimental medicine · 2021Article
- Advances and opportunities in malaria population genomics.Nature reviews. Genetics · 2021Review
- Mechanistic within-host models of the asexual Plasmodium falciparum infection: a review and analytical assessment.Malaria journal · 2021Article
- Immune selection suppresses the emergence of drug resistance in malaria parasites but facilitates its spread.PLoS computational biology · 2021Article
- Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malaria.PLoS genetics · 2021Article
- Co-transmission of Related Malaria Parasite Lineages Shapes Within-Host Parasite Diversity.Cell host & microbe · 2020Article
Corrections and comments
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Authors and funding
22 authors at 10 institutions in 6 countries.
Funding
Abstract
Host immunity exerts strong selective pressure on pathogens. Population-level genetic analysis can identify signatures of this selection, but these signatures reflect the net selective effect of all hosts and vectors in a population. In contrast, analysis of pathogen diversity within hosts provides information on individual, host-specific selection pressures. Here, we combine these complementary approaches in an analysis of the malaria parasite Plasmodium falciparum using haplotype sequences from thousands of natural infections in sub-Saharan Africa. We find that parasite genotypes show preferential clustering within multi-strain infections in young children, and identify individual amino acid positions that may contribute to strain-specific immunity. Our results demonstrate that natural host defenses to P. falciparum act in an allele-specific manner to block specific parasite haplotypes from establishing blood-stage infections. This selection partially explains the extreme amino acid diversity of many parasite antigens and suggests that vaccines targeting such proteins should account for allele-specific immunity.
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