ArticleTranslational psychiatry2018
Ghrelin is a persistent biomarker for chronic stress exposure in adolescent rats and humans.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 70 citations in OpenAlex.
- Transcutaneous vagal nerve stimulation modulates stress-induced plasma ghrelin levels: A double-blind, randomized, sham-controlled trial.Journal of affective disorders · 2023Trial
- Pharmacological manipulation of the ghrelin system and alcohol hangover symptoms in heavy drinking individuals: Is there a link?Pharmacology, biochemistry, and behavior · 2018Trial
- Striosomal ghrelin receptor activity controls reward-cost integration.Research square · 2026Article
- Sex-dependent behavioral and hypothalamic receptor changes after early-life monosodium glutamate (MSG) exposure and adult social stress in Wistar rats.Metabolic brain disease · 2026Article
- Neurobiology of resilience to early life stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Leptin Levels in Acute and Recovered Eating Disorders: An Arm-Based Network Meta-Analysis.European eating disorders review : the journal of the Eating Disorders Association · 2025Review
- GHS-R1a signaling drives anxiety-related behavior by shaping excitability of ventromedial hypothalamic neurons.Nature communications · 2025Article
- Evidence for independent actions of the CRF and ghrelin systems in binge-like alcohol drinking in mice.Progress in neuro-psychopharmacology & biological psychiatry · 2025Article
- Stress-induced GHS-R1a expression in medial prefrontal cortical neurons promotes vulnerability to anxiety in mice.Communications biology · 2025Article
- A Modular Customizable Ligand-Conjugate (LC) System Targeting GhrelinBiomolecules · 2025Article
- An Emerging Role for Gut-Brain Signaling Involving Ghrelin in Chronic Stress.Advances in experimental medicine and biology · 2025Review
- Bridging east and west: integrative approaches to obesity management through traditional Chinese medicine.Frontiers in endocrinology · 2025Review
- Leptin and ghrelin dynamics: unraveling their influence on food intake, energy balance, and the pathophysiology of type 2 diabetes mellitus.Journal of diabetes and metabolic disorders · 2024Review
- Leptin, Nesfatin-1, Orexin-A, and Total Ghrelin Levels in Drug-Naive Panic Disorder.Psychiatry investigation · 2024Article
- The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and therapeutically targeting maladaptive stress physiology.Stress (Amsterdam, Netherlands) · 2024Review
- Ghrelin as a Biomarker of "Immunometabolic Depression" and Its Connection with Dysbiosis.Nutrients · 2023Review
- Childhood sexual abuse is associated with higher total ghrelin serum levels in adulthood: results from a large, population-based study.Translational psychiatry · 2023Article
- Lower Ghrelin Levels Are Associated With Higher Anxiety Symptoms in Adolescents and Young Adults With Avoidant/Restrictive Food Intake Disorder.The Journal of clinical psychiatry · 2023Article
- Associations of early life stress with leptin and ghrelin in healthy young adults.Psychoneuroendocrinology · 2023Article
- Glucocorticoids, stress and eating: The mediating role of appetite-regulating hormones.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prolonged stressor exposure in adolescence enhances the risk of developing stress-sensitive mental illnesses, including posttraumatic stress disorder (PTSD), for many years following exposure cessation, but the biological underpinnings of this long-term vulnerability are unknown. We show that severe stressor exposure increased circulating levels of the hormone acyl-ghrelin in adolescent rats for at least 130 days and in adolescent humans for at least 4.5 years. Using a rodent model of longitudinal PTSD vulnerability in which rodents with a history of stressor exposure during adolescence display enhanced fear in response to fear conditioning administered weeks after stressor exposure ends, we show that systemic delivery of a ghrelin receptor antagonist for 4 weeks surrounding stressor exposure (2 weeks during and 2 weeks following) prevented stress-enhanced fear memory. These data suggest that protracted exposure to elevated acyl-ghrelin levels mediates a persistent vulnerability to stress-enhanced fear after stressor exposure ends.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.