Evidence map›Paper›PMID 29643358›Full record

ArticleTranslational psychiatry2018

Polygenic risk for schizophrenia and measured domains of cognition in individuals with psychosis and controls.

Rebecca Shafee, Pranav Nanda, Jaya L Padmanabhan, Neeraj Tandon, Ney Alliey-Rodriguez, Sreeja Kalapurakkel, Daniel J Weiner, Raquel E Gur, Richard S E Keefe, Scot K Hill and 9 more

Abstract read
In one paragraph

Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Rebecca ShafeeDepartment of Genetics, Harvard Medical School, Boston, MA, USA. rebecca_shafee@hms.harvard.edu.
Pranav NandaCollege of Physicians & Surgeons, Columbia University Medical Center, New York, NY, USA.
Jaya L PadmanabhanDepartment of Psychiatry and Cognitive Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Neeraj TandonBaylor College of Medicine, Texas Medical Center, Houston, TX, USA.
Ney Alliey-RodriguezDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
Sreeja KalapurakkelStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Daniel J WeinerStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Raquel E GurDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
Richard S E KeefeDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Scot K HillDepartment of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Jeffrey R BishopDepartment of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, USA.
Brett A ClementzDepartment of Psychology and Neuroscience, University of Georgia, Athens, GA, USA.
Carol A TammingaDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Elliot S GershonDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4818-8631
Godfrey D PearlsonDepartments of Psychiatry and Neurobiology, Yale University and Olin Neuropsychiatric Research Center, Hartford, CT, USA.
Matcheri S KeshavanDepartment of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boson, MA, USA.
John A SweeneyDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA.
Steven A McCarrollDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Elise B RobinsonStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Funding

Phenotypic profiling of ASD riskR01MH111813 · NIMH · BROAD INSTITUTE, INC. · PI ROBINSON, ELISE B · 2017 to 2021
$2.4M
The genomic bridge project (GBP)K01MH099286 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ROBINSON, ELISE B · 2013 to 2016
$647k
NIMH NIH HHS K01 MH099286NIMH NIH HHS R01 MH111813
6 · The paper itself

Abstract

Psychotic disorders including schizophrenia are commonly accompanied by cognitive deficits. Recent studies have reported negative genetic correlations between schizophrenia and indicators of cognitive ability such as general intelligence and processing speed. Here we compare the effect of polygenetic risk for schizophrenia (PRS

Indexed as

Genetic Predisposition to DiseaseMultifactorial InheritanceSchizophrenic PsychologyAdultCognitionFemaleHumansMaleMiddle AgedNeuropsychological TestsPolymorphism, Single NucleotidePsychotic DisordersRisk FactorsSchizophrenia

Identifiers

PMID29643358
PMCPMC5895806

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.