Evidence map›Paper›PMID 29643339›Full record

ArticleTranslational psychiatry2018

Desynchronization of diurnal rhythms in bipolar disorder and borderline personality disorder.

Oliver Carr, Kate E A Saunders, Amy C Bilderbeck, Athanasios Tsanas, Niclas Palmius, John R Geddes, Russell Foster, Maarten De Vos, Guy M Goodwin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The Regulatory Potential of Long Non-Coding RNAs in Bipolar Disorder.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Oliver CarrInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, OX3 7DQ, UK.ORCID http://orcid.org/0000-0003-1669-1005
Kate E A SaundersUniversity Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK.
Amy C BilderbeckUniversity Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK.
Athanasios TsanasUsher Institute of Population Health Sciences and Informatics, Medical School, University of Edinburgh, Edinburgh, EH16 4UX, UK.
Niclas PalmiusInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, OX3 7DQ, UK.
John R GeddesUniversity Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK.
Russell FosterSleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.ORCID http://orcid.org/0000-0001-6055-2067
Maarten De VosInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, OX3 7DQ, UK. maarten.devos@eng.ox.ac.uk.
Guy M GoodwinUniversity Department of Psychiatry, University of Oxford, Oxford, OX3 7JX, UK.

Funding

Medical Research Council MC_PC_17215Wellcome Trust 098461/Z/12/ZWellcome Trust 102616/Z
6 · The paper itself

Abstract

It has long been proposed that diurnal rhythms are disturbed in bipolar disorder (BD). Such changes are obvious in episodes of mania or depression. However, detailed study of patients between episodes has been rare and comparison with other psychiatric disorders rarer still. Our hypothesis was that evidence for desynchronization of diurnal rhythms would be evident in BD and that we could test the specificity of any effect by studying borderline personality disorder (BPD). Individuals with BD (n = 36), BPD (n = 22) and healthy volunteers (HC, n = 25) wore a portable heart rate and actigraphy device and used a smart-phone to record self-assessed mood scores 10 times per day for 1 week. Average diurnal patterns of heart rate (HR), activity and sleep were compared within and across groups. Desynchronization in the phase of diurnal rhythms of HR compared with activity were found in BPD (+3 h) and BD (+1 h), but not in HC. A clear diurnal pattern for positive mood was found in all subject groups. The coherence between negative and irritable mood and HR showed a four-cycle per day component in BD and BPD, which was not present in HC. The findings highlight marked de-synchronisation of measured diurnal function in both BD but particularly BPD and suggest an increased association with negative and irritable mood at ultradian frequencies. These findings enhance our understanding of the underlying physiological changes associated with BPD and BD, and suggest objective markers for monitoring and potential treatment targets. Improved mood stabilisation is a translational objective for management of both patient groups.

Indexed as

Circadian RhythmActigraphyAdultBipolar DisorderBorderline Personality DisorderFemaleHeart RateHumansMale

Identifiers

PMID29643339
PMCPMC5895697

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.