Evidence map›Paper›PMID 29643250›Full record

ArticleJournal of virology2018

Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency.

Jorge Ruben Cabrera, Audra J Charron, David A Leib

Abstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Novel mutations in UMolecular therapy. Methods & clinical development · 2023
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Upregulation of Multiple CD8Journal of immunology (Baltimore, Md. : 1950) · 2020
    Article
  15. Abortive herpes simplex virus infection of nonneuronal cells results in quiescent viral genomes that can reactivate.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jorge Ruben CabreraDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Audra J CharronDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
David A LeibDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA david.a.leib@dartmouth.edu.

Funding

Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2025
$25.9M
VIral and host mechanisms that tilt the HSV lytic/latent balanceP01AI098681 · NIAID · HARVARD MEDICAL SCHOOL · PI PESOLA, JEAN M · 2013 to 2023
$19.2M
VIRAL & HOST FACTORS IN HERPETIC REACTIVATIONR01EY009083 · NEI · WASHINGTON UNIVERSITY · PI David A Leib · 1992 to 2026
$10.3M
NEI NIH HHS R01 EY009083NIAID NIH HHS P01 AI098681NIGMS NIH HHS P20 GM113132
6 · The paper itself

Abstract

Herpes simplex virus (HSV) latency in neurons remains poorly understood, and the heterogeneity of the sensory nervous system complicates mechanistic studies. In this study, we used primary culture of adult trigeminal ganglion (TG) mouse neurons in microfluidic devices and an

Indexed as

Calcitonin Gene-Related PeptideCell Culture TechniquesCells, CulturedGene Expression Regulation, ViralHerpesvirus 1, HumanIntermediate FilamentsMicrofluidic Analytical TechniquesMicroRNAsPromoter Regions, GeneticSensory Receptor CellsVirus LatencyCalca protein, mouseCalcitonin Gene-Related Peptidelatency associated transcript, herpes simplex virus-1MicroRNAsherpes simplex viruslatencyneurons

Identifiers

PMID29643250
PMCPMC6002736

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.