Evidence map›Paper›PMID 29643202›Full record

ArticleJournal of clinical microbiology2018

Comparison of Diagnostic Accuracy of Periprosthetic Tissue Culture in Blood Culture Bottles to That of Prosthesis Sonication Fluid Culture for Diagnosis of Prosthetic Joint Infection (PJI) by Use of Bayesian Latent Class Modeling and IDSA PJI Criteria for Classification.

Qun Yan, Melissa J Karau, Kerryl E Greenwood-Quaintance, Jayawant N Mandrekar, Douglas R Osmon, Matthew P Abdel, Robin Patel

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 7 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 7 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
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  8. Contribution of sonication to the microbiology diagnosis of periprosthetic joint infection: Retrospective study of real-world data.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  9. Effect of sonication on staphylococcal and gram-negative biofilms relevant to prosthetic joint infections: an in vitro study.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Qun YanDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Melissa J KarauDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Kerryl E Greenwood-QuaintanceDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Jayawant N MandrekarDivison of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Douglas R OsmonDivision of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Matthew P AbdelDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Robin PatelDivision of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA patel.robin@mayo.edu.
Mayo Clinic · USMayo Clinic in Florida · USCentral South University · CN

Funding

Molecular Detection of Biofilms on Hip and Knee ImplantsR01AR056647 · NIAMS · MAYO CLINIC ROCHESTER · PI PATEL, ROBIN · 2009 to 2020
$4.5M
Disappearance of rifampin resistance in MRSA foreign body osteomyelitisR21AI125870 · NIAID · MAYO CLINIC ROCHESTER · PI PATEL, ROBIN · 2016 to 2017
$437k
NIAID NIH HHS R21 AI125870NIAMS NIH HHS R01 AR056647
6 · The paper itself

Abstract

We have previously demonstrated that culturing periprosthetic tissue in blood culture bottles (BCBs) improves sensitivity compared to conventional agar and broth culture methods for diagnosis of prosthetic joint infection (PJI). We have also shown that prosthesis sonication culture improves sensitivity compared to periprosthetic tissue culture using conventional agar and broth methods. The purpose of this study was to compare the diagnostic accuracy of tissue culture in BCBs (subsequently referred to as tissue culture) to prosthesis sonication culture (subsequently referred to as sonicate fluid culture). We studied 229 subjects who underwent arthroplasty revision or resection surgery between March 2016 and October 2017 at Mayo Clinic in Rochester, Minnesota. Using the Infectious Diseases Society of America (IDSA) PJI diagnostic criteria (omitting culture criteria) as the gold standard, the sensitivity of tissue culture was similar to that of the sonicate fluid culture (66.4% versus 73.1%,

Indexed as

AdultAgedAged, 80 and overBacteriological TechniquesBayes TheoremCell Culture TechniquesColony Count, MicrobialFemaleHumansMaleMiddle AgedProspective StudiesProsthesis-Related InfectionsReproducibility of ResultsSensitivity and SpecificitySonicationblood culture bottlesperiprosthetic tissue culturePJIprosthetic joint infectionsonicate fluid culture

Identifiers

PMID29643202
PMCPMC5971557
OpenAlexW2803147484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.