Evidence map›Paper›PMID 29643123›Full record

ArticleThe EMBO journal2018

Intragenic transcriptional interference regulates the human immune ligand MICA.

Da Lin, Thomas K Hiron, Christopher A O'Callaghan

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Da LinNuffield Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Thomas K HironNuffield Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Christopher A O'CallaghanNuffield Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK chris.ocallaghan@ndm.ox.ac.uk.ORCID 0000-0001-9962-3248
Centre for Human Genetics · GB

Funding

Medical Research Council G116/165
6 · The paper itself

Abstract

Many human genes have tandem promoters driving overlapping transcription, but the value of this distributed promoter configuration is generally unclear. Here we show that

Indexed as

Gene Expression RegulationPromoter Regions, GeneticTranscription, GeneticAutophagyCell NucleusDNA-Binding ProteinsHigh Mobility Group ProteinsHistocompatibility Antigens Class IHumansInterferon-gammaInterleukin-4NucleosomesProtein TransportTranscriptional Elongation FactorsDNA-Binding ProteinsHigh Mobility Group ProteinsHistocompatibility Antigens Class IIL4 protein, humanInterferon-gammaInterleukin-4MHC class I-related chain ANucleosomesSSRP1 protein, humanTranscriptional Elongation FactorsFACTMICANKG2Dtandem promotertranscriptional interference

Identifiers

PMID29643123
PMCPMC5978299
OpenAlexW2796696713

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.