Evidence map›Paper›PMID 29643120›Full record

ArticleEMBO reports2018

EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF.

Elena Groppa, Sime Brkic, Andrea Uccelli, Galina Wirth, Petra Korpisalo-Pirinen, Maria Filippova, Boris Dasen, Veronica Sacchi, Manuele Giuseppe Muraro, Marianna Trani and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 77 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Elena GroppaDepartment of Biomedicine, University Hospital, University of Basel, Basel, Switzerland.
Sime BrkicDepartment of Biomedicine, University Hospital, University of Basel, Basel, Switzerland.
Andrea UccelliDepartment of Biomedicine, University Hospital, University of Basel, Basel, Switzerland.
Galina WirthA. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.
Petra Korpisalo-PirinenA. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.
Maria FilippovaDepartment of Biomedicine, University Hospital, University of Basel, Basel, Switzerland.
Boris DasenDepartment of Biomedicine, University Hospital, University of Basel, Basel, Switzerland.
Veronica SacchiDepartment of Biomedicine, University Hospital, University of Basel, Basel, Switzerland.
Manuele Giuseppe MuraroDepartment of Biomedicine, University Hospital, University of Basel, Basel, Switzerland.
Marianna TraniDepartment of Biomedicine, University Hospital, University of Basel, Basel, Switzerland.
Silvia ReginatoDepartment of Biomedicine, University Hospital, University of Basel, Basel, Switzerland.
Roberto Gianni-BarreraDepartment of Biomedicine, University Hospital, University of Basel, Basel, Switzerland.
Seppo Ylä-HerttualaA. I. Virtanen Institute, University of Eastern Finland, Kuopio, Finland.
Andrea BanfiDepartment of Biomedicine, University Hospital, University of Basel, Basel, Switzerland andrea.banfi@usb.ch.ORCID 0000-0001-5737-8811
University of Basel · CHUniversity of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular endothelial growth factor (VEGF) is the master regulator of angiogenesis, whose best-understood mechanism is sprouting. However, therapeutic VEGF delivery to ischemic muscle induces angiogenesis by the alternative process of intussusception, or vascular splitting, whose molecular regulation is essentially unknown. Here, we identify ephrinB2/EphB4 signaling as a key regulator of intussusceptive angiogenesis and its outcome under therapeutically relevant conditions. EphB4 signaling fine-tunes the degree of endothelial proliferation induced by specific VEGF doses during the initial stage of circumferential enlargement of vessels, thereby limiting their size and subsequently enabling successful splitting into normal capillary networks. Mechanistically, EphB4 neither inhibits VEGF-R2 activation by VEGF nor its internalization, but it modulates VEGF-R2 downstream signaling through phospho-ERK1/2.

Indexed as

Signal TransductionAnimalsCells, CulturedEndothelial CellsEphrin-B2FemaleHumansIntussusceptionIschemiaMiceMice, Inbred C57BLMice, KnockoutMice, SCIDMuscle, SkeletalMyoblastsNeovascularization, PathologicEphrin-B2Receptor, EphB4Vascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2EphB4EphrinB2intussusceptionvascular endothelial growth factor

Identifiers

PMID29643120
PMCPMC5934775
OpenAlexW2796637672

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.