Evidence map›Paper›PMID 29643111›Full record

ArticleJournal of the American Heart Association2018

Cardiovascular and Cerebrovascular Emergency Department Visits Associated With Wildfire Smoke Exposure in California in 2015.

Zachary S Wettstein, Sumi Hoshiko, Jahan Fahimi, Robert J Harrison, Wayne E Cascio, Ana G Rappold

Abstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Society for Cardiovascular Magnetic Resonance recommendations toward environmentally sustainable cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Guideline
  2. Pooled it
  3. Health Effects of Wildfire Smoke Exposure.Annual review of medicine · 2024
    Pooled it
  4. The Effect of Fire Smoke Exposure on Firefighters' Lung Function: A Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
  5. Pooled it
  6. Article
  7. Article
  8. Article
  9. Stroke and climate change: A World Stroke Organization scientific statement.International journal of stroke : official journal of the International Stroke Society · 2026
    Review
  10. Article
  11. Wildfire smoke-related PMEnvironment international · 2026
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Wildfire and asthma - The prospective interventions.The World Allergy Organization journal · 2025
    Review
  18. Article
  19. Article
  20. Review

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zachary S WettsteinSchool of Medicine, University of California San Francisco, San Francisco, CA.
Sumi HoshikoEnvironmental Health Investigations Branch, California Department of Public Health, Richmond, CA.
Jahan FahimiDepartment of Emergency Medicine, University of California San Francisco, San Francisco, CA.
Robert J HarrisonDepartment of Medicine, University of California San Francisco, San Francisco, CA.
Wayne E CascioNational Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Durham, NC.
Ana G RappoldNational Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Durham, NC rappold.ana@epa.gov.

Funding

NRSA Training CoreTL1TR001871 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SOMSOUK, MA · 2016 to 2025
$10.1M
NCATS NIH HHS TL1 TR001871NIOSH CDC HHS R13 OH009753NIOSH CDC HHS R25 OH008802
6 · The paper itself

Abstract

backgroundWildfire smoke is known to exacerbate respiratory conditions; however, evidence for cardiovascular and cerebrovascular events has been inconsistent, despite biological plausibility. METHODS AND

resultsA population-based epidemiologic analysis was conducted for daily cardiovascular and cerebrovascular emergency department (ED) visits and wildfire smoke exposure in 2015 among adults in 8 California air basins. A quasi-Poisson regression model was used for zip code-level counts of ED visits, adjusting for heat index, day of week, seasonality, and population. Satellite-imaged smoke plumes were classified as light, medium, or dense based on model-estimated concentrations of fine particulate matter. Relative risk was determined for smoky days for lag days 0 to 4. Rates of ED visits by age- and sex-stratified groups were also examined. Rates of all-cause cardiovascular ED visits were elevated across all lags, with the greatest increase on dense smoke days and among those aged ≥65 years at lag 0 (relative risk 1.15, 95% confidence interval [1.09, 1.22]). All-cause cerebrovascular visits were associated with smoke, especially among those 65 years and older, (1.22 [1.00, 1.49], dense smoke, lag 1). Respiratory conditions were also increased, as anticipated (1.18 [1.08, 1.28], adults >65 years, dense smoke, lag 1). No association was found for the control condition, acute appendicitis. Elevated risks for individual diagnoses included myocardial infarction, ischemic heart disease, heart failure, dysrhythmia, pulmonary embolism, ischemic stroke, and transient ischemic attack.

conclusionsAnalysis of an extensive wildfire season found smoke exposure to be associated with cardiovascular and cerebrovascular ED visits for all adults, particularly for those over aged 65 years.

Indexed as

FiresAgedAir PollutantsCaliforniaCardiovascular DiseasesCerebrovascular DisordersEmergency Service, HospitalEnvironmental ExposureFemaleFollow-Up StudiesHospitalizationHumansIncidenceMaleParticulate MatterRetrospective StudiesAir PollutantsParticulate Matterheart failureischemic heart diseaseparticulate matterstrokewildfire

Identifiers

PMID29643111
PMCPMC6015400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.