ArticleNeurology2018
Age at menopause and lifetime cognition: Findings from a British birth cohort study.
Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- The Prevalence of Symptomatic Knee Osteoarthritis in Relation to Age, Sex, Area, Region, and Body Mass Index in China: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2020Pooled it
- The influence of sex on cognition in psychosis.Schizophrenia research. Cognition · 2026Article
- The interaction of diet-induced obesity and chronic stress in a mouse model of menopause.Hormones and behavior · 2026Article
- Chronological age is differentially associated with cognitive performance according to climacteric stage: evidence from a Bayesian multivariate analysis in Chilean women.Frontiers in psychology · 2026Article
- Age at natural menopause, reproductive lifespan and Alzheimer's disease in females: is APOE ε4 the missing link?Frontiers in genetics · 2026Article
- Membrane-associated estrogen receptor α prevents the amyloid β-induced suppression of GIRK channel activity in hippocampal neurons from female mice.Biology of sex differences · 2025Article
- The Association Between Age of Menopause and Hysterectomy Status and Alzheimer's Disease Risk in a Cohort of Older White and Black Women.Journal of women's health (2002) · 2025Article
- One size does not fit all: how type of menopause and hormone therapy matters for brain health.The British journal of psychiatry : the journal of mental science · 2025Review
- Cognitive Function in Peri- and Postmenopausal Women: Implications for Considering Iron Supplementation.Nutrients · 2025Review
- Age at menopause and cognitive function and decline among middle-aged and older women in the China Health and Retirement Longitudinal Study, 2011-2018.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- A Case for estradiol: younger brains in women with earlier menarche and later menopause.GigaScience · 2025Article
- Effect of early menopause on cognition and brain morphology in an Urban Indian Cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults.Communications biology · 2024Article
- Evaluation of the relationship between types of menopause and cognitive function.Turkish journal of medical sciences · 2024Article
- Article
- The effect of hormone replacement therapy on cognition and mood.Clinical endocrinology · 2023Review
- [Cognitive and psychoemotional changes in menopausal transition: The possibility of medical correction].Problemy endokrinologii · 2023Article
- Sex Differences in Dementia.Current topics in behavioral neurosciences · 2023Review
- Sex Differences in Cognition Across Aging.Current topics in behavioral neurosciences · 2023Review
- The Interplay Among Natural Menopause, Insomnia, and Cognitive Health: A Population-Based Study.Nature and science of sleep · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe investigated whether cognitive performance between ages 43 and 69 years was associated with timing of menopause, controlling for hormone replacement therapy, childhood cognitive ability, and sociobehavioral factors.
methodsWe used data from 1,315 women participating in the Medical Research Council National Survey of Health and Development (a British birth cohort study) with known age at period cessation and up to 4 assessments of verbal memory (word-learning task) and processing speed (letter-cancellation task) at ages 43, 53, 60-64, and 69. We fitted multilevel models with linear and quadratic age terms, stratified by natural or surgical menopause, and adjusted for hormone replacement therapy, body mass index, smoking, occupational class, education, and childhood cognitive ability.
resultsVerbal memory increased with later age at natural menopause (0.17 words per year, 95% confidence interval [CI]: 0.07-0.27,
conclusionOur findings suggest lifelong hormonal processes, not just short-term fluctuations during the menopause transition, may be associated with verbal memory, consistent with evidence from a variety of neurobiological studies; mechanisms are likely to involve estrogen receptor β function. Further follow-up is required to assess fully the clinical significance of these associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.