Evidence map›Paper›PMID 29642915›Full record

ArticleJournal of ovarian research2018

Adipokine RBP4 drives ovarian cancer cell migration.

Yanyan Wang, Yilin Wang, Zhenyu Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
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  11. Mechanisms by which obesity regulates inflammation and anti-tumor immunity in cancer.Biochemical and biophysical research communications · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yanyan WangDepartment of Gynaecology and Obstetrics, Beijing Chaoyang Hospital, Capital Medical University, No. 8 South Road, workers' Stadium, Chaoyang District, Beijing, 100020, China.
Yilin WangDepartment of Gynaecology and Obstetrics, Beijing Chaoyang Hospital, Capital Medical University, No. 8 South Road, workers' Stadium, Chaoyang District, Beijing, 100020, China.
Zhenyu ZhangDepartment of Gynaecology and Obstetrics, Beijing Chaoyang Hospital, Capital Medical University, No. 8 South Road, workers' Stadium, Chaoyang District, Beijing, 100020, China. zhenyuzhang2000@163.com.
Beijing Chaoyang Emergency Medical Center · CN

Funding

National Natural Science Foundation of China 81571455
6 · The paper itself

Abstract

backgroundObesity has been linked to several types of cancers including ovarian cancer. Retinol binding protein 4 (RBP4) is an adipokine that drives the development of hyperinsulinemia and type II diabetes in obesity patients and animals. Previously, we have identified RBP4 as a serum marker for ovarian cancer. Here we further explored the consequence of RBP4 upregulation in ovarian cancer cells and its molecular mechanism.

resultsOur results show that RBP4 is overexpressed in ovarian cancer cells to the same extent as in adipose tissues. The overexpression of RBP4 in ovarian cancer cells promotes cancer cell migration and proliferation. At molecular level, cancer progression factors MMP2 and MMP9 are induced in response to RBP4 overexpression. We further investigated which signaling pathways are utilized by RBP4 to activate ovarian cancer cell migration. We found RhoA/Rock1 pathway is turned on and CyclinD1 is upregulated in RBP4 overexpressed cells. Inhibition of RhoA/Rock1 pathway reduces the RBP4-induced MMP2 and MMP9 expression. The RBP4 action is depend on its associated ligand vitamin A/retinol acid (RA) and possibly involves similar pathways as for conferring insulin resistance. Moreover, we show that knockdown of RBP4 significantly reduce cancer cell migration and proliferation as well as expressions of oncogenic factors.

conclusionsOur results indicated that RBP4 can drive ovarian cancer cell migration and proliferation via RhoA/Rock1 and ERK pathway. It suggests that RBP4 act as a oncogene in ovarian cancer cells. Thus, RBP4 could be a molecular bridge between obesity and cancers and a potential target for treating obese cancer patients.

Indexed as

AdipokinesCell Line, TumorCell MovementCell ProliferationCyclin D1FemaleHumansOvarian NeoplasmsProtein BindingRetinol-Binding Proteins, PlasmarhoA GTP-Binding Proteinrho-Associated KinasesSignal TransductionTretinoinAdipokinesCyclin D1RBP4 protein, humanRetinol-Binding Proteins, PlasmarhoA GTP-Binding Proteinrho-Associated KinasesROCK1 protein, humanTretinoinMigrationObesityOvarian cancerRBP4Retinol acid

Identifiers

PMID29642915
PMCPMC5896151
OpenAlexW2800914260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.