ArticleBMC biotechnology2018
Antiplasmodial and trypanocidal activity of violacein and deoxyviolacein produced from synthetic operons.
Article in BMC biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Violacein: a natural antibacterial agent empowered by film-forming sprays for topical applications.BMC complementary medicine and therapies · 2025Article
- Violacein-Loaded Outer Membrane Vesicles fromACS biomaterials science & engineering · 2025Article
- Evaluation of Violacein Metabolic Stability and Metabolite Identification in Human, Mouse, and Rat Liver Microsomes.Pharmaceutics · 2025Article
- Article
- Pigments from pathogenic bacteria: a comprehensive update on recent advances.World journal of microbiology & biotechnology · 2024Review
- Purification of Natural Pigments Violacein and Deoxyviolacein Produced by Fermentation UsingMolecules (Basel, Switzerland) · 2023Article
- Bacterial Pigments and Their Multifaceted Roles in Contemporary Biotechnology and Pharmacological Applications.Microorganisms · 2023Review
- Expanding the application of tryptophan: Industrial biomanufacturing of tryptophan derivatives.Frontiers in microbiology · 2023Review
- Evaluation of the anti-proliferative activity of violacein, a natural pigment of bacterial origin, in urinary bladder cancer cell lines.Oncology letters · 2022Article
- Sex, ancestry, senescence, and aging (SAnSA) are stark drivers of nontuberculous mycobacterial pulmonary disease.Journal of clinical tuberculosis and other mycobacterial diseases · 2022Review
- Multi-target drug with potential applications: violacein in the spotlight.World journal of microbiology & biotechnology · 2021Review
- Violacein improves recombinant IgG production by controlling the cell cycle of Chinese hamster ovary cells.Cytotechnology · 2021Article
- Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity.ACS infectious diseases · 2021Article
- Biotechnological Activities and Applications of Bacterial Pigments Violacein and Prodigiosin.Journal of biological engineering · 2021Review
- A Golden-Gate Based Cloning Toolkit to Build Violacein Pathway Libraries inACS synthetic biology · 2021Article
- Integrated into Environmental BiofilmMicroorganisms · 2020Article
- Assessment ofRSC advances · 2020Article
- A Biosynthetic Platform for Antimalarial Drug Discovery.Antimicrobial agents and chemotherapy · 2020Article
- Brought to you courtesy of the red, white, and blue-pigments of nontuberculous mycobacteria.AIMS microbiology · 2020Article
- Enhanced deoxyviolacein bioproduction via enzyme condensation with a yeast glycolytic enzyme-derived peptide tag.Biotechnology progressArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundViolacein is a deep violet compound that is produced by a number of bacterial species. It is synthesized from tryptophan by a pathway that involves the sequential action of 5 different enzymes (encoded by genes vioA to vioE). Violacein has antibacterial, antiparasitic, and antiviral activities, and also has the potential of inducing apoptosis in certain cancer cells.
resultsHere, we describe the construction of a series of plasmids harboring the complete or partial violacein biosynthesis operon and their use to enable production of violacein and deoxyviolacein in E.coli. We performed in vitro assays to determine the biological activity of these compounds against Plasmodium, Trypanosoma, and mammalian cells. We found that, while deoxyviolacein has a lower activity against parasites than violacein, its toxicity to mammalian cells is insignificant compared to that of violacein.
conclusionsWe constructed E. coli strains capable of producing biologically active violacein and related compounds, and propose that deoxyviolacein might be a useful starting compound for the development of antiparasite drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.