ArticleBMC complementary and alternative medicine2018
Antiproliferative activities and phenolic acid content of water and ethanolic extracts of the powdered formula of Houttuynia cordata Thunb. fermented broth and Phyllanthus emblica Linn. fruit.
Article in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Development ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Isolation and validation of antimalarial compounds from Phyllanthus emblica leaves for new antimalarial drug development.Scientific reports · 2025Article
- Genotoxic and Anti-Genotoxic Assessments of FermentedFoods (Basel, Switzerland) · 2024Article
- Chemopreventive Potential ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Phenolic acids from medicinal and edible homologous plants: a potential anti-inflammatory agent for inflammatory diseases.Frontiers in immunology · 2024Review
- Effect of Extraction Methods on the Antioxidant Potential and Cytotoxicity of the Combined Ethanolic Extracts ofMolecules (Basel, Switzerland) · 2023Article
- Article
- Anti-cancer Effect and Active Phytochemicals of Houttuynia cordata Thunb. against Human Breast Cancer Cells.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Review
- The therapeutic potential ofHeliyon · 2022Review
- Structural modification of olibergin A, an isoflavonoid, fromRSC advances · 2022Article
- Histone Deacetylase Inhibitory Activity and Antiproliferative Potential of New [6]-Shogaol Derivatives.Molecules (Basel, Switzerland) · 2022Article
- Four New Anthraquinones with Histone Deacetylase Inhibitory Activity fromMolecules (Basel, Switzerland) · 2022Article
- Scalarane Sesterterpenoids with Antibacterial and Anti-Proliferative Activities from the MushroomMolecules (Basel, Switzerland) · 2021Article
- Dalpulapans A-E from the roots ofRSC advances · 2021Article
- Medicinal Plants with Anti-Leukemic Effects: A Review.Molecules (Basel, Switzerland) · 2021Review
- The Effects ofMolecules (Basel, Switzerland) · 2020Article
- Tannic acid elicits selective antitumoral activity in vitro and inhibits cancer cell growth in a preclinical model of glioblastoma multiforme.Metabolic brain disease · 2020Article
- An Insight Into the Modulatory Effects and Mechanisms of Action ofFrontiers in pharmacology · 2019Review
- Phyllanthus emblica leaf extract ameliorates testicular damage in rats with chronic stress.Journal of Zhejiang University. Science. BArticle
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHouttuynia cordata Thunb. and Phyllanthus emblica Linn. are native plants with medicinal and nutritive significance in Asia. The present study was aimed at evaluating antiproliferative effects on human cancer cell lines and identifying the phenolic acid composition of water and ethanolic extracts of the powdered formula of H. cordata fermented broth and P. emblica fruit.
methodsAnticancer activity of the extracts was evaluated against HeLa, HT29, HCT116, MCF7 and Jurkat cells using an MTT assay and flow cytometric analysis of apoptosis induction and cell cycle arrest. Reverse phase HPLC was exploited for identification and quantification of some phenolic acids.
resultsMTT assay showed that both water and ethanolic extracts significantly decreased the viability of cancer cells in a dose- and time-dependent fashion. Based on the IC
conclusionOverall, the results of this study suggest the powdered formula of H. cordata fermented broth and P. emblica fruit as an alternative medicine for cancer prevention and treatment.
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