Evidence map›Paper›PMID 29642587›Full record

ArticleViruses2018

Pervasive Chimerism in the Replication-Associated Proteins of Uncultured Single-Stranded DNA Viruses.

Darius Kazlauskas, Arvind Varsani, Mart Krupovic

Abstract read
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. The Journal of general virology · 2025
    Article
  7. Article
  8. Article
  9. Phylogeographic analysis ofThe Journal of general virology · 2024
    Article
  10. Article
  11. Article
  12. Genomoviruses in Liver Samples ofMicroorganisms · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Darius KazlauskasInstitute of Biotechnology, Vilnius University, Saulėtekio Av. 7, Vilnius 10257, Lithuania. d.kazlauskas@ibt.lt.
Arvind VarsaniThe Biodesign Center for Fundamental and Applied Microbiomics, School of Life Sciences, Center for Evolution and Medicine, Arizona State University, Tempe, AZ 85287, USA. arvind.varsani@asu.edu.ORCID 0000-0003-4111-2415
Mart KrupovicUnité Biologie Moléculaire du Gène chez les Extrêmophiles, Department of Microbiology, Institut Pasteur, 25 rue du Docteur Roux, Paris 75015, France. krupovic@pasteur.fr.ORCID 0000-0001-5486-0098

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous metagenomic studies have uncovered a remarkable diversity of circular replication-associated protein (Rep)-encoding single-stranded (CRESS) DNA viruses, the majority of which are uncultured and unclassified. Unlike capsid proteins, the Reps show significant similarity across different groups of CRESS DNA viruses and have conserved domain organization with the N-terminal nuclease and the C-terminal helicase domain. Consequently, Rep is widely used as a marker for identification, classification and assessment of the diversity of CRESS DNA viruses. However, it has been shown that in certain viruses the Rep nuclease and helicase domains display incongruent evolutionary histories. Here, we systematically evaluated the co-evolutionary patterns of the two Rep domains across classified and unclassified CRESS DNA viruses. Our analysis indicates that the Reps encoded by members of the families

Indexed as

ChimerismPhylogenyDNA, Single-StrandedDNA VirusesEvolution, MolecularGenome, ViralMetagenomicsProtein DomainsViral ProteinsDNA, Single-StrandedViral ProteinsCRESS DNA virusesHUH endonuclease domainrecombinationrolling-circle replication initiation proteinsssDNA virusessuperfamily 3 helicase domainvirus evolution

Identifiers

PMID29642587
PMCPMC5923481

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.