ReviewNutrients2018
Should We Prescribe More Protein to Critically Ill Patients?
Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- High-protein home parenteral nutrition in malnourished oncology patients: a systematic literature review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Pooled it
- Protein-Energy Wasting Assessment and Clinical Outcomes in Patients with Acute Kidney Injury: A Systematic Review with Meta-Analysis.Nutrients · 2020Pooled it
- Article
- Physiological barriers to oral intake in survivors of critical illness: A scoping review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Article
- Article
- Parenteral Nutrition Overview.Nutrients · 2022Review
- Nutrition in the Intensive Care Unit-A Narrative Review.Nutrients · 2021Review
- Metabolism of Proteins and Amino Acids in Critical Illness: From Physiological Alterations to Relevant Clinical Practice.Journal of multidisciplinary healthcare · 2021Review
- Mounting Clarity on Enteral Feeding in Critically Ill Patients.American journal of respiratory and critical care medicine · 2020Article
- Advances in Medical Nutrition Therapy: Parenteral Nutrition.Nutrients · 2020Review
- Rationale for and Design of the Study of Early Enteral Dextrose in Sepsis: A Pilot Placebo-Controlled Randomized Clinical Trial.JPEN. Journal of parenteral and enteral nutrition · 2020Article
- Is Energy Delivery Guided by Indirect Calorimetry Associated With Improved Clinical Outcomes in Critically Ill Patients? A Systematic Review and Meta-analysis.Nutrition and metabolic insights · 2020Article
- Impact of a High-protein Nutritional Intake on the Clinical Outcome of the Neurocritical Patients.Iranian journal of pharmaceutical research : IJPR · 2020Article
- Preserving the quality of life: nutrition in the ICU.Critical care (London, England) · 2019Review
- How to achieve nutrition goals by actual nutrition guidelines.Critical care (London, England) · 2019Article
- Reliability of ultrasound measurements of quadriceps muscle thickness in critically ill patients.BMC anesthesiology · 2018Observational
- High protein intake during the early phase of critical illness: yes or no?Critical care (London, England) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the context of critical illness, evidence suggests that exogenous protein/amino acid supplementation has the potential to favorably impact whole-body protein balance. Whether this translates into retention of muscle, greater muscle strength, and improved survival and physical recovery of critically ill patients remains uncertain. The purpose of this brief commentary is to provide an overview of the clinical evidence for and against increasing protein doses and to introduce two new trials that will add considerably to our evolving understanding of protein requirements in the critically ill adult patient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.