Evidence map›Paper›PMID 29642377›Full record

ArticlePharmacy (Basel, Switzerland)2018

Benzodiazepines Withdrawal: Initial Outcomes and Long-Term Impact on Falls in a French Nursing Home.

Hervé Javelot, Anne Marquis, Emilie Antoine-Bernard, Jean Grandidier, Luisa Weiner, Thierry Javelot, Bruno Michel

Open access · goldAbstract read
In one paragraph

Article in Pharmacy (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Deprescribing-A Few Steps Further.Pharmacy (Basel, Switzerland) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Hervé JavelotMaison Hospitalière de Baccarat, 54120 Baccarat, France. herve.javelot@ch-epsan.fr.
Anne MarquisMaison Hospitalière de Baccarat, 54120 Baccarat, France. mhbpharma@free.fr.
Emilie Antoine-BernardMaison Hospitalière de Baccarat, 54120 Baccarat, France.
Jean GrandidierMaison Hospitalière de Baccarat, 54120 Baccarat, France. mhbmedical@free.fr.
Luisa WeinerClinique Psychiatrique, Service de Psychiatrie II, Hôpital Civil, CHU de Strasbourg, 67091 Strasbourg, France. luisa.weiner@chru-strasbourg.fr.
Thierry JavelotEquipe de Liaison et de Soins en Addictologie, C.H. Saint Jean de Dieu, 69008 Lyon, France. t.javelot@clinique-le-sermay.fr.
Bruno MichelService Pharmacie, CHU de Strasbourg, Faculté de Pharmacie, EA7396, 67091 Strasbourg, France. bruno.michel@chru-strasbourg.fr.ORCID 0000-0001-5961-1584
Centre Hospitalier de Saint Jean de Dieu · FRHôpital Civil, Strasbourg · FRObservatoire Régional de la Santé d’Alsace · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term use of benzodiazepines (BZDs) is known to induce tolerance and dependence, and increase the risk of falls-related injuries in older adults. We present a study carried out in a French nursing home that concerns the implementation of a BZD withdrawal program reassessed at one year. BZD deprescription was achieved by gradual cessation of doses. A secondary benefit of this program was assessed by comparing the number of falls among residents before and after withdrawal. The number of falls was recorded over a six-month period prior to the onset of withdrawal (T1) and then over a six-month period after reassessment at one year (T2). At the beginning, 31 (28.7%) of the patients were under BZD. Total deprescription was obtained for 11 patients. The number of falls per patient over the T1 period was not different between the two groups (future non-withdrawn and withdrawn patients in BZD): 2.1 ± 1.3 and 2.3 ± 0.6 falls per resident, respectively. Conversely, the number of falls per patient was significantly decreased in the population completely withdrawn in BZD between the T1 and T2 periods (2.3 ± 0.6 vs. 0.5 ± 0.2 falls,

Indexed as

benzodiazepinedeprescriptionfallolder patientswithdrawal

Identifiers

PMID29642377
PMCPMC6024993
OpenAlexW2795985537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.