Evidence map›Paper›PMID 29642372›Full record

ArticleNutrients2018

ω-3 and ω-6 Fatty Acids Modulate Conventional and Atypical Protein Kinase C Activities in a Brain Fatty Acid Binding Protein Dependent Manner in Glioblastoma Multiforme.

Marwa E Elsherbiny, Hua Chen, Marwan Emara, Roseline Godbout

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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  13. Fatty acid-binding proteins: functional understanding and diagnostic implications.Current opinion in clinical nutrition and metabolic care · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Marwa E ElsherbinyDepartment of Pharmacology and Toxicology, Ahram Canadian University, 6th of October City, Giza 12566, Egypt. marwae@ualberta.ca.
Hua ChenDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G 1Z2, Canada. Hua.Chen@albertahealthservices.ca.
Marwan EmaraCenter for Aging and Associated Diseases, Zewail City of Science and Technology, Giza 12578, Egypt. memara@zewailcity.edu.eg.
Roseline GodboutDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G 1Z2, Canada. rgodbout@ualberta.ca.ORCID 0000-0002-4779-9265
University of Alberta · CAAhram Canadian University · EGZewail City of Science and Technology · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is a highly infiltrative brain cancer with a dismal prognosis. High levels of brain fatty acid binding protein (B-FABP) are associated with increased migration/infiltration in GBM cells, with a high ratio of arachidonic acid (AA) to docosahexaenoic acid (DHA) driving B-FABP-mediated migration. Since several protein kinase Cs (PKCs) are overexpressed in GBM and linked to migration, we explored a possible relationship between B-FABP and levels/activity of different PKCs, as a function of AA and DHA supplementation. We report that ectopic expression of B-FABP in U87 cells alters the levels of several PKCs, particularly PKC

Indexed as

Arachidonic AcidBrain NeoplasmsCell Line, TumorDocosahexaenoic AcidsFatty Acid-Binding Protein 7Gene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticGlioblastomaHumansProtein Kinase CSignal TransductionTumor Suppressor ProteinsArachidonic AcidDocosahexaenoic AcidsFABP7 protein, humanFatty Acid-Binding Protein 7PKC-3 proteinProtein Kinase CTumor Suppressor Proteinsarachidonic acidbrain fatty acid binding proteindocosahexaenoic acidGlioblastoma multiformeprotein kinase C

Identifiers

PMID29642372
PMCPMC5946239
OpenAlexW2795408153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.