SynthesisMedicine2018
Association between interleukin 37 (rs3811047) polymorphism and multiple autoimmune diseases in a Chinese population: A PRISMA-compliant meta-analysis.
Synthesis in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of IL-37 levels and genetic variants with systemic lupus erythematosus: a meta-analysis.Scientific reports · 2025Pooled it
- Elevated serum IL-18 and IL-37 levels and their association with seizure burden in paediatric epilepsy.Frontiers in immunology · 2026Article
- Role of Interleukin 37 and its polymorphism (rs3811047) in children with type I diabetes.Molecular biology reports · 2025Article
- Relationship between Cytokines and Metabolic Syndrome Components: Role of Pancreatic-Derived Factor, Interleukin-37, and Tumor Necrosis Factor-α in Metabolic Syndrome Patients.Indian journal of clinical biochemistry : IJCB · 2024Article
- Interleukin-37: associations of plasma levels and genetic variants in gout.Arthritis research & therapy · 2023Article
- Interleukin-37 gene polymorphism and susceptibility to coronavirus disease 19 among Iraqi patients.Meta gene · 2022Article
- Serum interleukin-37 level and interleukin-37 gene polymorphism in patients with Behçet disease.Clinical rheumatology · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEmerging evidence suggests that interleukin 37 (IL-37) plays an important role in the pathogenesis of several autoimmune diseases (ADs), but the correlations are still unclear. We conducted a meta-analysis to explore whether IL-37 gene (rs3811047) polymorphism was associated with susceptibility to multiple ADs in a Chinese population.
methodsRelevant studies were searched in the PubMed, Embase, Chinese National Knowledge Infrastructure, and Chinese Wangfang databases up to August 31, 2017. Odds ratio (OR) and its 95% confidence interval (95% CI) was used to estimate the strength of the association in different genetic models. The results of fixed or random models were adopted according to the heterogeneity. Publication bias and sensitive analysis were also performed to evaluate the reliability of results.
resultsA total of 3161 patients and 4078 controls from 6 studies were included in this meta-analysis. Pooling all data together, a significant association between IL-37 gene (rs3811047 A/G) polymorphism and susceptibility to ADs in the Chinese population was found in all 4 genetic models (allelic model A vs G: OR = 0.73 95% CI = 0.67∼0.79; recessive model AA + AG vs GG: OR = 0.72, 95% CI = 0.65∼0.79; dominant model AA vs AG + GG: OR = 0.59, 95% CI = 0.45∼0.77; homozygous model AA vs GG: OR = 0.55, 95% CI = 0.42∼0.72). No heterogeneity and publication bias was detected in all models. Sensitive analysis indicated that all of the positive results are reliable.
conclusionThe IL- 37 (rs3811047) polymorphism contributes to the development of ADs in a Chinese population.
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