Evidence map›Paper›PMID 29642171›Full record

ArticleMedicine2018

Over-the-counter analgesic powder use in patients presenting with intracerebral hemorrhage: A case series.

Syed Ali Raza, Laura Beth Durm, Ghada A Mahmoud, Haseeb Rahman, Laura Henriquez, Brittaine Davis, Fadi Nahab

Open access · goldAbstract read
In one paragraph

Article in Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Not so Goody's powder.BMJ case reports · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Syed Ali RazaDepartment of Neurology, Emory University Department of Neurology, Emory University Hospital, Atlanta, GA Department of Neurology, Henry Ford Health System, Detroit, MI, USA.
Laura Beth Durm
Ghada A Mahmoud
Haseeb Rahman
Laura Henriquez
Brittaine Davis
Fadi Nahab
Emory University · USEmory University Hospital · USHenry Ford Health System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOver-the-counter (OTC) analgesics including aspirin-containing powder formulations (BC Powder, Goody's Powder) (ACPFs) are commonly utilized in the United States. While the ACPFs have been associated with upper gastrointestinal bleeding, we describe a case series of patients presenting with intracerebral hemorrhage (ICH) within 24 hours of ingestion.

methodsWe reviewed all ICH patients presenting to a comprehensive stroke center from September 1, 2014 through June 30, 2016 to identify patients who reported taking BC Powder or Goody's Powder within 7 days of their stroke. Baseline characteristics, medication use, stroke risk factors, clinical imaging, and laboratory testing were reviewed retrospectively.

resultsOf 334 patients admitted with ICH during the study period, 6 (2%) reported use of OTC analgesic powders within 1 week of their index stroke. All had consumed at least 1 packet within 24 hours of their ICH. All patients were African American and all except 1 patient were females. Three patients had no identified traditional stroke risk factors and 3 other patients had evidence of mild hypertension history.

conclusionsOver-the-counter analgesic powders containing high doses of aspirin including BC Powder and Goody's Powder may contribute to ICH in patients with no or minimal risk factors. Providers should inquire about the use of these powders in ICH patients particularly among African Americans.

Indexed as

AcetaminophenAdultAgedAnalgesicsAspirinBlack or African AmericanCerebral HemorrhageDose-Response Relationship, DrugDrug CombinationsFemaleHumansMaleMiddle AgedNonprescription DrugsPowdersRetrospective StudiesAcetaminophenAnalgesicsAspirinDrug CombinationsNonprescription DrugsPowders

Identifiers

PMID29642171
PMCPMC5908640
OpenAlexW2803552714

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.